The complex world of emaraviruses—Challenges, insights, and prospects

M Rehanek, DG Karlin, M Bandte, R Al Kubrusli… - Forests, 2022 - mdpi.com
Emaravirus (Order Bunyavirales; Family Fimoviridae) is a genus comprising over 20
emerging plant viruses with a worldwide distribution and economic impact. Emaraviruses …

Post-proline cleaving enzymes (PPCEs): classification, structure, molecular properties, and applications

A Baharin, TY Ting, HH Goh - Plants, 2022 - mdpi.com
Proteases or peptidases are hydrolases that catalyze the breakdown of polypeptide chains
into smaller peptide subunits. Proteases exist in all life forms, including archaea, bacteria …

Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy

L del Amo-Maestro, SR Mendes… - Nature …, 2022 - nature.com
The digestion of gluten generates toxic peptides, among which a highly immunogenic
proline-rich 33-mer from wheat α-gliadin, that trigger coeliac disease. Neprosin from the …

Postproline Cleaving Enzymes also Show Specificity to Reduced Cysteine

Z Kalaninová, JM Portašiková, B Jireckova… - Analytical …, 2024 - ACS Publications
In proteomics, postproline cleaving enzymes (PPCEs), such as Aspergillus niger prolyl
endopeptidase (An PEP) and neprosin, complement proteolytic tools because proline is a …

Omics approaches in uncovering molecular evolution and physiology of botanical carnivory

A Baharin, TY Ting, HH Goh - Plants, 2023 - mdpi.com
Systems biology has been increasingly applied with multiple omics for a holistic
comprehension of complex biological systems beyond the reductionist approach that …

Characterization of the Cannabis sativa glandular trichome epigenome

LJ Conneely, B Hurgobin, S Ng, M Tamiru-Oli… - BMC Plant …, 2024 - Springer
Background The relationship between epigenomics and plant specialised metabolism
remains largely unexplored despite the fundamental importance of epigenomics in gene …

[HTML][HTML] GPpred: A Novel Sequence-Based Tool for Predicting Glutamic Proteases Using Optimized Hybrid Encodings

A Firoz, A Malik, N Mahajan, HM Ali, MR Kamli, CB Kim - Catalysts, 2024 - mdpi.com
Glutamic proteases (GPs) represent one of the seven peptidase families described in the
MEROPS database of peptidases (also known as proteases, proteinases, and proteolytic …

[HTML][HTML] Specificity Enhancement of Glutenase Bga1903 toward Celiac Disease-Eliciting Pro-Immunogenic Peptides via Active-Site Modification

YY Liu, RL Ye, M Meng - International Journal of Molecular Sciences, 2023 - mdpi.com
Celiac disease is an autoimmune disease triggered by oral ingestion of gluten, with certain
gluten residues resistant to digestive tract enzymes. Within the duodenum, the remaining …

The Arabidopsis DUF239 gene family encodes Neprosin‐like proteins that are widely expressed in seed endosperm

V Vergès, L Bellenger, O Pichon… - The Plant …, 2023 - Wiley Online Library
Abstract Domain of unknown function 239 (DUF239) is a conserved sequence found in the
catalytic site of Neprosins which are specific secreted prolyl endopeptidases found in the …

Overview of the Properties of Glutamic Peptidases That Are Present in Plant and Bacterial Pathogens and Play a Role in Celiac Disease and Cancer

K Oda, A Wlodawer - Biochemistry, 2023 - ACS Publications
Seven peptidase (proteinase) families─ aspartic, cysteine, metallo, serine, glutamic,
threonine, and asparagine─ are in the peptidase database MEROPS, version 12.4 …