Tackling fungal resistance by biofilm inhibitors

S Wu, Y Wang, N Liu, G Dong… - Journal of Medicinal …, 2017 - ACS Publications
The high incidence and mortality of invasive fungal infections and serious drug resistance
have become a global public health issue. The ability of fungal cells to form biofilms is an …

Screening repurposing libraries for identification of drugs with novel antifungal activity

G Wall, JL Lopez-Ribot - Antimicrobial Agents and Chemotherapy, 2020 - Am Soc Microbiol
Fungal organisms are ubiquitous in nature, and progress of modern medicine is creating an
expanding number of severely compromised patients susceptible to a variety of …

[HTML][HTML] Ultra-fast proteomics with Scanning SWATH

CB Messner, V Demichev, N Bloomfield, JSL Yu… - Nature …, 2021 - nature.com
Accurate quantification of the proteome remains challenging for large sample series and
longitudinal experiments. We report a data-independent acquisition method, Scanning …

Antimicrobial potential of green synthesized CeO2 nanoparticles from Olea europaea leaf extract

Q Maqbool, M Nazar, S Naz, T Hussain… - International journal …, 2016 - Taylor & Francis
This article reports the green fabrication of cerium oxide nanoparticles (CeO2 NPs) using
Olea europaea leaf extract and their applications as effective antimicrobial agents. O …

Prediction of multidimensional drug dose responses based on measurements of drug pairs

A Zimmer, I Katzir, E Dekel… - Proceedings of the …, 2016 - National Acad Sciences
Finding potent multidrug combinations against cancer and infections is a pressing
therapeutic challenge; however, screening all combinations is difficult because the number …

Repurposing and optimization of drugs for discovery of novel antifungals

MJ Donlin, MJ Meyers - Drug discovery today, 2022 - Elsevier
Highlights•There is a dire need for novel antifungal therapies.•Recent clinical trials of directly
repurposed drugs have failed.•The most recently approved antifungals underwent …

[HTML][HTML] Antifungal drug repurposing

JH Kim, LW Cheng, KL Chan, CC Tam, N Mahoney… - Antibiotics, 2020 - mdpi.com
Control of fungal pathogens is increasingly problematic due to the limited number of
effective drugs available for antifungal therapy. Conventional antifungal drugs could also …

Eucalyptol/β-cyclodextrin inclusion complex loaded gellan/PVA nanofibers as antifungal drug delivery system

P Mishra, P Gupta, AK Srivastava, KM Poluri… - International Journal of …, 2021 - Elsevier
Fungal infections pose a serious threat to humankind due to the toxicity of conventional
antifungal therapy and continuous emerging incidence of multidrug resistance. Essential oils …

[HTML][HTML] Drug repurposing in medical mycology: Identification of compounds as potential antifungals to overcome the emergence of multidrug-resistant fungi

L Peyclit, H Yousfi, JM Rolain, F Bittar - Pharmaceuticals, 2021 - mdpi.com
Immunodepression, whether due to HIV infection or organ transplantation, has increased
human vulnerability to fungal infections. These conditions have created an optimal …

[HTML][HTML] Combination therapy to treat fungal biofilm-based infections

J Tits, BPA Cammue, K Thevissen - International Journal of Molecular …, 2020 - mdpi.com
An increasing number of people is affected by fungal biofilm-based infections, which are
resistant to the majority of currently-used antifungal drugs. Such infections are often caused …