Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause
of heart failure leading to premature death. Several CMPs are now recognized to have a …

Arrhythmogenic cardiomyopathy (ACM) is a familial, nonischemic heart disease typically
inherited via an autosomal dominant pattern (Nava et al.,[1]; Wlodarska et al.,[2]). Often …

Nuclear factor κ-B (NFκB) is activated in iPSC-cardiac myocytes from patients with
arrhythmogenic cardiomyopathy (ACM) under basal conditions, and inhibition of NFκB …

Poly (dimethylsiloxane)(PDMS) is a commonly used polymer in organ-on-a-chip devices
and microphysiological systems. However, due to its hydrophobicity and permeability, it …

Voltage-gated sodium channels (Nav channels) support the genesis and brisk spatial
propagation of action potentials in the heart. Disruption of NaV1. 5 inactivation results in a …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

Arrhythmogenic cardiomyopathy (ACM) is a hereditary myocardial disease characterized by
the replacement of the ventricular myocardium with fibrous fatty deposits. ACM is usually …

Engineered heart tissues have been created to study cardiac biology and disease in a
setting that more closely mimics in vivo heart muscle than 2D monolayer culture. Previously …

Arrhythmogenic cardiomyopathy (AC) is a heritable, potentially lethal disease without a
causal therapy. AC is characterized by focal cardiomyocyte death followed by inflammation …

Inhibition of nuclear factor kappa-B (NF kappa B) signaling prevents disease in
Dsg2mut/mut mice, a model of arrhythmogenic cardiomyopathy (ACM). Moreover, NF kappa …