Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

A Verkhratsky, M Augusto-Oliveira, A Pivoriūnas… - … -European Journal of …, 2021 - Springer
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity

A Popov, A Brazhe, P Denisov, O Sutyagina, L Li… - Aging cell, 2021 - Wiley Online Library
Little is known about age‐dependent changes in structure and function of astrocytes and of
the impact of these on the cognitive decline in the senescent brain. The prevalent view on …

Mitochondrial malfunction and atrophy of astrocytes in the aged human cerebral cortex

A Popov, N Brazhe, K Morozova, K Yashin… - Nature …, 2023 - nature.com
How aging affects cells of the human brain active milieu remains largely unknown. Here, we
analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and older …

[HTML][HTML] Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction

J Henf, MJ Grothe, K Brueggen, S Teipel, M Dyrba - NeuroImage: Clinical, 2018 - Elsevier
Mean diffusivity (MD) measured by diffusion tensor imaging can reflect microstructural
alterations of the brain's gray matter (GM). Therefore, GM MD may be a sensitive marker of …

What can DTI tell about early cognitive impairment?–Differentiation between MCI subtypes and healthy controls by diffusion tensor imaging

G Gyebnár, Á Szabó, E Sirály, Z Fodor… - Psychiatry Research …, 2018 - Elsevier
Mild cognitive impairment (MCI) gained a lot of interest recently, especially that the
conversion rate to Alzheimer Disease (AD) in the amnestic subtype (aMCI) is higher than in …

Male brain ages faster: the age and gender dependence of subcortical volumes

A Király, N Szabó, E Tóth, G Csete, P Faragó… - Brain imaging and …, 2016 - Springer
Abstract Effects of gender on grey matter (GM) volume differences in subcortical structures of
the human brain have consistently been reported. Recent research evidence suggests that …

Age-and memory-related differences in hippocampal gray matter integrity are better captured by NODDI compared to single-tensor diffusion imaging

A Venkatesh, SM Stark, CEL Stark, IJ Bennett - Neurobiology of Aging, 2020 - Elsevier
Single-tensor diffusion imaging (DTI) has traditionally been used to assess integrity of white
matter. For example, we previously showed that integrity of limbic white matter tracts …

Age‐related alterations in human cortical microstructure across the lifespan: Insights from high‐gradient diffusion MRI

H Lee, HH Lee, Y Ma, L Eskandarian, K Gaudet… - Aging …, 2024 - Wiley Online Library
The human brain undergoes age‐related microstructural alterations across the lifespan.
Soma and Neurite Density Imaging (SANDI), a novel biophysical model of diffusion MRI …

Exercise training-related changes in cortical gray matter diffusivity and cognitive function in mild cognitive impairment and healthy older adults

DD Callow, J Won, GS Pena, LS Jordan… - Frontiers in aging …, 2021 - frontiersin.org
Individuals with Mild Cognitive Impairment (MCI) are at an elevated risk of dementia and
exhibit deficits in cognition and cortical gray matter (GM) volume, thickness, and …