Male fertility is closely related to the normal function of the hypothalamicpituitary-testicular
axis. The testis is an important male reproductive organ that secretes androgen and …

Mammalian spermatogenesis is a highly complex multi-step process sustained by a
population of mitotic germ cells with self-renewal potential known as spermatogonial stem …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …

The intricate interaction between spermatogonial stem cell (SSC) and testicular niche is
essential for maintaining SSC homeostasis; however, this interaction remains largely …

Objectives Fibroblast growth factor 9 (FGF9) is expressed by somatic cells in the
seminiferous tubules, yet little information exists about its role in regulating spermatogonial …

Maintenance of male fertility requires spermatogonial stem cells (SSCs) that self-renew and
generate differentiating germ cells for production of spermatozoa. Germline cells are …

Spermatogonial stem cells (SSCs) sustain spermatogenesis by balancing self-renewal and
initiation of differentiation to produce progenitor spermatogonia committed to forming sperm …

In mouse testis, a heterogeneous population of undifferentiated spermatogonia (A undiff)
harbors spermatogenic stem cell (SSC) potential. Although GFRα1+ A undiff maintains the …

Abstract Background and Purpose Damage to the testis following exposure to ionizing
radiation has become an urgent problem to be solved. Here we have investigated if …

Adult male fertility depends on spermatogonial stem cells (SSCs) which undergo either self-
renewal or differentiation in response to microenvironmental signals. Activin A acts on …