A platform for experimental precision medicine: The extended BXD mouse family
The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …
phenotypes, development, environments, and treatments. We address this challenge by …
BXD recombinant inbred mice as a model to study neurotoxicity
BXD recombinant inbred (RI) lines represent a genetic reference population derived from a
cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic …
cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic …
The expanded BXD family of mice: a cohort for experimental systems genetics and precision medicine
The challenge of precision medicine is to model complex interactions among DNA variants,
sets of phenotypes, and complex environmental factors and confounders. We have …
sets of phenotypes, and complex environmental factors and confounders. We have …
Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel
Cocaine self‐administration is a complexly determined trait, with a substantial proportion of
individual differences being determined by genetic variation. However, the relevant genetic …
individual differences being determined by genetic variation. However, the relevant genetic …
Private and sub-family specific mutations of founder haplotypes in the BXD family reveal phenotypic consequences relevant to health and disease
The BXD recombinant inbred (RI) mouse strains are the largest and most deeply
phenotyped inbred panel of vertebrate organisms. RIs allow phenotyping of isogenic …
phenotyped inbred panel of vertebrate organisms. RIs allow phenotyping of isogenic …
Environmental enrichment influences novelty reactivity, novelty preference, and anxiety via distinct genetic mechanisms in C57BL/6J and DBA/2J mice
PE Dickson, G Mittleman - Scientific Reports, 2021 - nature.com
Environmental factors such as stress drive the development of drug addiction in genetically
vulnerable individuals; the genes underlying this vulnerability are unknown. One strategy for …
vulnerable individuals; the genes underlying this vulnerability are unknown. One strategy for …
Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice
M Leonardo, S Brunty, J Huffman, A Kastigar… - Scientific Reports, 2023 - nature.com
The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are
unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis …
unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis …
New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork
Gene-by-environment interactions are important for all facets of biology, especially
behaviour. Families of isogenic strains of mice, such as the BXD strains, are excellently …
behaviour. Families of isogenic strains of mice, such as the BXD strains, are excellently …
Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats
AM Gancarz, DP Hagarty, MM Cobb, MA Kausch… - …, 2023 - Springer
Rationale An important facet of cocaine addiction is a high propensity to relapse, with
increasing research investigating factors that predispose individuals toward uncontrolled …
increasing research investigating factors that predispose individuals toward uncontrolled …
Effects of isolation housing stress and mouse strain on intravenous cocaine self-administration, sensory stimulus self-administration, and reward preference
M Leonardo, S Brunty, J Huffman, DB Lester… - Scientific Reports, 2023 - nature.com
Sensory stimuli are natural rewards in mice and humans. Consequently, preference for a
drug reward relative to a sensory reward may be an endophenotype of addiction …
drug reward relative to a sensory reward may be an endophenotype of addiction …