Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease
Cutaneous mast cells (MCs) express Mas-related G protein–coupled receptor-X2
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …
Unlocking the non-IgE-mediated pseudo-allergic reaction puzzle with mas-related G-protein coupled receptor member X2 (MRGPRX2)
Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR
expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell …
expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell …
Therapeutic potential of MRGPRX2 inhibitors on mast cells
H Ogasawara, M Noguchi - Cells, 2021 - mdpi.com
Mast cells (MCs) act as primary effectors in inflammatory and allergic reactions by releasing
intracellularly-stored inflammatory mediators in diseases. The two major pathways for MC …
intracellularly-stored inflammatory mediators in diseases. The two major pathways for MC …
MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs
G Al Hamwi, YK Riedel, S Clemens… - Pharmacology & …, 2022 - Elsevier
MAS-related G protein-coupled receptors (GPCRs) of subfamily X, designated MRGPRX,
are primate-specific orphan receptors that belong to the δ-branch of rhodopsin-like, class A …
are primate-specific orphan receptors that belong to the δ-branch of rhodopsin-like, class A …
[HTML][HTML] Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective
Atopic dermatitis (AD) is an inflammatory disorder centered around loss of epidermal barrier
function, and T helper 2 (Th2) immune responses. The current understanding of disease …
function, and T helper 2 (Th2) immune responses. The current understanding of disease …
Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist
M Bawazir, A Amponnawarat, Y Hui… - Frontiers in …, 2022 - frontiersin.org
Mas-related G protein-coupled receptor-X2 (MRGPRX2) expressed on mast cells (MCs)
contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) …
contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) …
Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists
J Wollam, M Solomon, C Villescaz, M Lanier… - Journal of Allergy and …, 2024 - Elsevier
Background Mas-related G protein–coupled receptor X2 (MRGPRX2) is a promiscuous
receptor on mast cells that mediates IgE-independent degranulation and has been …
receptor on mast cells that mediates IgE-independent degranulation and has been …
The multifaceted mas-related G protein-coupled receptor member X2 in allergic diseases and beyond
PL Quan, M Sabaté-Brescó, Y Guo, M Martín… - International Journal of …, 2021 - mdpi.com
Recent research on mast cell biology has turned its focus on MRGPRX2, a new member of
the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in …
the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in …
Osthole: An up-to-date review of its anticancer potential and mechanisms of action
S Yang, W Dai, J Wang, X Zhang, Y Zheng… - Frontiers in …, 2022 - frontiersin.org
With its high incidence and mortality rates, cancer is one of the largest health problems
worldwide. Investigating various cancer treatment options has been the focus of many …
worldwide. Investigating various cancer treatment options has been the focus of many …
The MRGPR family of receptors in immunity
N Gour, X Dong - Immunity, 2024 - cell.com
The discovery of Mas-related G protein-coupled receptors (Mrgprs) has opened a
compelling chapter in our understanding of immunity and sensory biology. This family of …
compelling chapter in our understanding of immunity and sensory biology. This family of …