[HTML][HTML] Fish toxicity testing for identification of thyroid disrupting chemicals

ZC Dang, M Arena, A Kienzler - Environmental Pollution, 2021 - Elsevier
Identification of thyroid disrupting chemicals (TDCs), one of the most studied types of
endocrine disruptors (EDs), is required according to EU regulations on industrial chemicals …

Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption

AC Haigis, L Vergauwen, CA LaLone… - Toxicological …, 2023 - academic.oup.com
Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

[HTML][HTML] Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole

L Yu, M Chen, Y Liu, W Gui, G Zhu - Aquatic toxicology, 2013 - Elsevier
The widely used triazole fungicides have the potential to disrupt endocrine system, but little
is known of such effects or underlying mechanisms of hexaconazole (HEX) and …

Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption

D Knapen, E Stinckens, JE Cavallin… - Environmental …, 2020 - ACS Publications
A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …

Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products

JI Webster, EM Sternberg - Journal of Endocrinology, 2004 - joe.bioscientifica.com
The present study was undertaken to investigate heat stress protein (HSP)-70 mRNA
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …

Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish

M Heijlen, AM Houbrechts, E Bagci… - …, 2014 - academic.oup.com
Exposure to appropriate levels of thyroid hormones (THs) at the right time is of key
importance for normal development in all vertebrates. Type 3 iodothyronine deiodinase (D3) …

Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae

S Zhang, X Guo, S Lu, N Sang, G Li, P Xie, C Liu… - Environmental …, 2018 - Elsevier
Perfluorododecanoic acid (PFDoA), a kind of perfluorinated carboxylic acid (PFCA) with 12
carbon atoms, has an extensive industrial utilization and is widespread in both wildlife and …

Deiodinases and thyroid metabolism disruption in teleost fish

S Jarque, B Piña - Environmental Research, 2014 - Elsevier
Many xenobiotic compounds with endocrine disrupting activity have been described since
the late eighties. These compounds are able to interact with natural hormone systems and …

Intracellular thyroid hormone metabolism as a local regulator of nuclear thyroid hormone receptor-mediated impact on vertebrate development

VM Darras, AM Houbrechts, SLJ Van Herck - Biochimica et Biophysica Acta …, 2015 - Elsevier
Abstract Background Thyroid hormones (THs) play an essential role in vertebrate
development, acting predominantly via nuclear TH receptors (TRs) which are ligand …

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish

Y Horie, M Nomura, K Okamoto… - Journal of Applied …, 2022 - Wiley Online Library
We compared the influence of thyroid hormone‐disrupting chemicals (heptafluorobutanoic
acid, PFBA and tris [1, 3‐dichloro‐2‐propyl] phosphate, TDCPP) and thyroid hormone (3 …