The suprachiasmatic nucleus at 50: looking back, then looking forward

D Ono, DR Weaver, MH Hastings… - Journal of biological …, 2024 - journals.sagepub.com
It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the
central circadian clock and 25 years since the last overview of developments in the field was …

On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus

JA Evans, WJ Schwartz - Journal of Comparative Physiology A, 2024 - Springer
Decades have now passed since Colin Pittendrigh first proposed a model of a circadian
clock composed of two coupled oscillators, individually responsive to the rising and setting …

Tempo: an unsupervised Bayesian algorithm for circadian phase inference in single-cell transcriptomics

BJ Auerbach, GA FitzGerald, M Li - Nature Communications, 2022 - nature.com
The circadian clock is a 24 h cellular timekeeping mechanism that regulates human
physiology. Answering several fundamental questions in circadian biology will require joint …

Generation and disruption of circadian rhythms in the suprachiasmatic nucleus: a core-shell model

AV Goltsev, EAP Wright… - Journal of Biological …, 2022 - journals.sagepub.com
We focus our research on how the core-shell organization controls behavior of the
suprachiasmatic nucleus (SCN), how the core and shell are synchronized to the …

Nested calcium dynamics support daily cell unity and diversity in the suprachiasmatic nuclei of free-behaving mice

L El Cheikh Hussein, P Fontanaud, P Mollard… - PNAS …, 2022 - academic.oup.com
The suprachiasmatic nuclei (SCN) of the anterior hypothalamus host the circadian
pacemaker that synchronizes mammalian rhythms with the day–night cycle. SCN neurons …

Applications of Single-Cell Genomics in the Study of Circadian and Vascular Biology

B Auerbach - 2023 - search.proquest.com
Single-cell RNA-sequencing (scRNA-seq) offers a powerful approach for studying genome-
wide mRNA levels within single cells at high-throughput. Using this tool, researchers can …