The role of neutrophil extracellular traps in cancer progression and metastasis

ML De Meo, JD Spicer - Seminars in immunology, 2021 - Elsevier
Neutrophil extracellular traps (NET) are the extracellular release of decondensed chromatin
and granules known for their role in host defense against foreign pathogens. However, a …

Portal vein thrombosis: diagnosis, management, and endpoints for future clinical studies

L Elkrief, V Hernandez-Gea, M Senzolo… - The lancet …, 2024 - thelancet.com
Portal vein thrombosis (PVT) refers to the development of a non-malignant obstruction of the
portal vein, its branches, its radicles, or a combination. This Review first provides a …

JAK2V617F mutation is highly prevalent in patients with ischemic stroke: a case-control study

MH Kristiansen, L Kjær, V Skov, MK Larsen… - Blood …, 2023 - ashpublications.org
Ischemic stroke has a high recurrence rate despite treatment. This underlines the
significance of investigating new possible cerebrovascular risk factors, such as the acquired …

JAK2V617F variant allele frequency >50% identifies patients with polycythemia vera at high risk for venous thrombosis

P Guglielmelli, GG Loscocco, C Mannarelli… - Blood cancer …, 2021 - nature.com
Arterial (AT) and venous (VT) thrombotic events are the most common complications in
patients with polycythemia vera (PV) and are the leading causes of morbidity and mortality …

[HTML][HTML] Platelets and neutrophils cooperate to induce increased neutrophil extracellular trap formation in JAK2V617F myeloproliferative neoplasms

A Guy, G Garcia, V Gourdou-Latyszenok… - Journal of Thrombosis …, 2024 - Elsevier
Background Neutrophils participate in the pathogenesis of thrombosis through the formation
of neutrophil extracellular traps (NETs). Thrombosis is the main cause of morbidity and …

Contributions of bone marrow monocytes/macrophages in myeloproliferative neoplasms with JAK2V617F mutation

W Fan, W Cao, J Shi, F Gao, M Wang, L Xu, F Wang… - Annals of …, 2023 - Springer
The classic BCR-ABL1-negative myeloproliferative neoplasm (MPN) is a highly
heterogeneous hematologic tumor that includes three subtypes, namely polycythemia vera …

Molecular Mechanisms Underlying Vascular Liver Diseases: Focus on Thrombosis

L Giuli, M Pallozzi, G Venturini, A Gasbarrini… - International Journal of …, 2023 - mdpi.com
Vascular liver disorders (VLDs) comprise a wide spectrum of clinical-pathological entities
that primarily affect the hepatic vascular system of both cirrhotic and non-cirrhotic patients …

Platelet thromboxane inhibition by low‐dose aspirin in polycythemia vera: Ex vivo and in vivo measurements and in silico simulation

G Petrucci, A Giaretta, P Ranalli… - Clinical and …, 2022 - Wiley Online Library
Low‐dose aspirin is currently recommended for patients with polycythemia vera (PV), a
myeloproliferative neoplasm with increased risk of arterial and venous thromboses. Based …

[HTML][HTML] The possible role of mutated endothelial cells in myeloproliferative neoplasms

M Farina, D Russo, R Hoffman - haematologica, 2021 - ncbi.nlm.nih.gov
Myeloproliferative neoplasms (MPN) are chronic, clonal hematologic malignancies
characterized by myeloproliferation and a high incidence of vascular complications …

The Power of Extracellular Vesicles in Myeloproliferative Neoplasms:“Crafting” a Microenvironment That Matters

L Catani, M Cavo, F Palandri - Cells, 2021 - mdpi.com
Myeloproliferative Neoplasms (MPN) are acquired clonal disorders of the hematopoietic
stem cells and include Essential Thrombocythemia, Polycythemia Vera and Myelofibrosis …