A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT),
hepatoblastoma (HB), and other embryonal tumors. Here, we outline these rare syndromes …

Pediatric renal tumors account for 3%–11% of childhood cancers, the most common of
which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer …

Developing synchronous bilateral Wilms tumor suggests an underlying (epi) genetic
predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or …

Results The overall mutation detection rate was high at 57%(97% in CNS and 41% in
SRNS); 85% of all mutations were identified by the analysis of three single genes only …

Since previous consensus-based Wilms tumour (WT) surveillance guidelines were
published, novel genes and syndromes associated with WT risk have been identified, and …

The objective of this article is to present an overview of recent trends in the management of
Wilms' tumor. With improved survival rates in the past few decades, critical long-term …

Historically, specific mutations in WT1 gene have been associated with distinct syndromes
based on phenotypic characteristics, including Denys-Drash syndrome (DDS), Frasier …

Congenital nephrotic syndrome (CNS) is a heterogeneous group of disorders presenting
with massive proteinuria within the first 3 months of life almost inevitably leading to end …

In this exciting era of" next-gen cytogenetics," integrating genomic sequencing into the
prenatal diagnostic setting is possible within an actionable time frame and can provide …

Idiopathic steroid-resistant nephrotic syndrome (SRNS) is most frequently characterized by
focal segmental glomerulosclerosis (FSGS) but also other histological lesions, such as …