Obesity surgery remains the most effective treatment for obesity and its complications.
Weight loss was initially attributed to decreased energy absorption from the gut but has …

A high intratumoral nerve density is correlated with poor survival, high metastasis, and high
recurrence across multiple solid tumor types. Recent research has revealed that cancer cells …

The endocannabinoid system (ECS) is an important brain modulatory network. ECS
regulates brain homeostasis throughout development, from progenitor fate decision to neuro …

Obesity is a complex, multifactorial disease that is a major public health issue worldwide.
Currently approved anti-obesity medications and lifestyle interventions lack the efficacy and …

Gut-brain signaling controls food intake and energy homeostasis, and its activity is thought
to be dysregulated in obesity. We will explore new studies that suggest the …

Obesity is a complex metabolic condition considered a worldwide public health crisis, and a
deeper mechanistic understanding of obesity-associated diseases is urgently needed …

Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes
adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of …

Objective RGS2 is a GTPase activating protein that modulates GPCR-G α signaling and
mice lacking RGS2 globally exhibit metabolic alterations. While RGS2 is known to be …

Evidence supports various roles for microbial metabolites in the control of multiple aspects of
host energy flux including feeding behaviors, digestive efficiency, and energy expenditure …

Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of
cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly …