[HTML][HTML] Advances in phenazines over the past decade: review of their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic …

J Yan, W Liu, J Cai, Y Wang, D Li, H Hua, H Cao - Marine Drugs, 2021 - mdpi.com
Phenazines are a large group of nitrogen-containing heterocycles, providing diverse
chemical structures and various biological activities. Natural phenazines are mainly isolated …

[HTML][HTML] Pyrazine and phenazine heterocycles: platforms for total synthesis and drug discovery

RW Huigens III, BR Brummel, S Tenneti, AT Garrison… - Molecules, 2022 - mdpi.com
There are numerous pyrazine and phenazine compounds that demonstrate biological
activities relevant to the treatment of disease. In this review, we discuss pyrazine and …

Burkholderia as a Source of Natural Products

S Kunakom, AS Eustáquio - Journal of natural products, 2019 - ACS Publications
Burkholderia bacteria are multifaceted organisms that are ecologically and metabolically
diverse. The Burkholderia genus has gained prominence because it includes human …

Biosynthesis, regulation, and engineering of natural products from Lysobacter

H Yue, AL Miller, V Khetrapal, V Jayaseker… - Natural Product …, 2022 - pubs.rsc.org
Covering: up to August 2021 Lysobacter is a genus of Gram-negative bacteria that was
classified in 1987. Several Lysobacter species are emerging as new biocontrol agents for …

[HTML][HTML] Quinoxaline 1, 4-dioxides: advances in chemistry and chemotherapeutic drug development

GI Buravchenko, AE Shchekotikhin - Pharmaceuticals, 2023 - mdpi.com
N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse
biological properties. The high reactivity and tendency to undergo various rearrangements …

[HTML][HTML] Type Strains of Entomopathogenic Nematode-Symbiotic Bacterium Species, Xenorhabdus szentirmaii (EMC) and X. budapestensis (EMA), Are Exceptional …

A Fodor, M Gualtieri, M Zeller, E Tarasco, MG Klein… - Pathogens, 2022 - mdpi.com
Antimicrobial multidrug resistance (MDR) is a global challenge, not only for public health,
but also for sustainable agriculture. Antibiotics used in humans should be ruled out for use in …

Metabolic Engineering of Pseudomonas chlororaphis for De Novo Production of Iodinin from Glycerol

S Guo, Y Zong, S Yue, H Hu, W Wang… - ACS Sustainable …, 2022 - ACS Publications
Iodinin, a natural phenazine N-oxide, is generally derived from phenazine-1, 6-dicarboxylic
acid (PDC) and has been widely used in the pharmacological and therapeutic fields …

[HTML][HTML] Anticancer activity in planctomycetes

R Calisto, EF Sæbø, JE Storesund, L Øvreås… - Frontiers in Marine …, 2019 - frontiersin.org
There is a strong need to develop new drugs against many severe diseases. Therapy
resistance is a major problem, for instance, in infectious diseases and cancer. Drug …

Designing an Artificial Pathway for the Biosynthesis of a Novel Phenazine N-Oxide in Pseudomonas chlororaphis HT66

S Guo, R Liu, W Wang, H Hu, Z Li… - ACS Synthetic …, 2020 - ACS Publications
Aromatic N-oxides are valuable due to their versatile chemical, pharmaceutical, and
agricultural applications. Natural phenazine N-oxides possess potent biological activities …

[HTML][HTML] Resistance-nodulation-division efflux pump, LexABC, contributes to self-resistance of the phenazine di-N-oxide natural product myxin in Lysobacter …

Y Zhao, J Liu, T Jiang, R Hou, G Xu, H Xu… - Frontiers in …, 2021 - frontiersin.org
Antibiotic-producing microorganisms have developed several self-resistance mechanisms to
protect them from autotoxicity. Transporters belonging to the resistance-nodulation-division …