2H/4H-Chromenes—A versatile biologically attractive Scaffold

V Raj, J Lee - Frontiers in Chemistry, 2020 - frontiersin.org
2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile
biological profiles, a simple structure, and mild adverse effects. Researchers discovered …

Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies

V Patel, T Bambharoliya, D Shah… - Current Topics in …, 2024 - ingentaconnect.com
Synthetic routes of chromene are an area of thrust research due to its wide application as
pigments, agrochemicals, cosmetics, and an important nucleus scaffold for various …

Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis …

MH Ahagh, G Dehghan, M Mehdipour… - Bioorganic …, 2019 - Elsevier
Amino-1-aryl-1H-benzo [f] chromene-2-carbonitrile derivatives were synthesized from three-
component reaction of arylaldehyde, malononitrile and 2-naphthol in the presence of 1, 4 …

Synthesis, Cytotoxic Activity, Crystal Structure, DFT Studies and Molecular Docking of 3-Amino-1-(2,5-dichlorophenyl)-8-methoxy-1H-benzo[f]chromene-2 …

M El Gaafary, T Syrovets, H M. Mohamed… - Crystals, 2021 - mdpi.com
The target compound 3-amino-1-(2, 5-d ichlorophenyl)-8-methoxy-1 H-benzo [f]-chromene-2-
carbonitrile (4) was synthesized via a reaction of 6-methoxynaphthalen-2-ol (1), 2, 5 …

Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo [h] chromene

FF Alblewi, RM Okasha, ZM Hritani, HM Mohamed… - Bioorganic …, 2019 - Elsevier
Novel β-enaminonitrile/ester compounds (4, 6) and an imidate of 4 (9) were utilized as key
scaffolds for the synthesis of newly 2-substituted 4H-benzo [h] chromene (7, 8, 10, 11, 13 …

4, 6-Diamino-2-thiopyrimidine-based Cobalt Metal Organic Framework (Co-DAT‐MOF): green, efficient, novel and reusable nanocatalyst for synthesis of …

A Ghorbani-Choghamarani, Z Kakakhani… - Scientific Reports, 2023 - nature.com
In this study, Co-DAT‐MOF powder was prepared via the solvothermal method using 4, 6-
diamino-2-thiopyrimidine as the organic linker and Co (NO3) 2· 6H2O. The synthesized …

Design, synthesis and molecular docking studies of novel triazole‐chromene conjugates as antitubercular, antioxidant and antifungal agents

SP Khare, TR Deshmukh, JN Sangshetti… - …, 2018 - Wiley Online Library
A green and efficient protocol has been developed for the synthesis of novel 1, 2, 3‐triazole‐
chromene conjugates (7 a‐j) via ultrasound assisted and NaHCO3 catalyzed for the first …

First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone …

RM Okasha, M Alsehli, S Ihmaid, SS Althagfan… - Bioorganic …, 2019 - Elsevier
This report presents the development of a novel and primary model of sulfonamide
compounds encompassing a chromene azo motif with the intent of becoming applicable for …

A new triazine-thiophene based porous organic polymer as efficient catalyst for the synthesis of chromenes via multicomponent coupling and catalyst support for facile …

SK Das, S Chatterjee, S Mondal, A Bhaumik - Molecular Catalysis, 2019 - Elsevier
Functionalized porous organic polymers are very demanding and promising material in
heterogeneous catalysis due to their convenience in synthesis and versatility in framework …

Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis

FF Alblewi, RM Okasha, AA Eskandrani, TH Afifi… - Molecules, 2019 - mdpi.com
Novel fused chromenes (4, 7–11) and pyrimidines (12–16) were designed, synthesized, and
evaluated for their mammary gland breast cancer (MCF-7), human colon cancer (HCT-116) …