[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Retinal vasculopathy in Alzheimer's disease

H Shi, Y Koronyo, A Rentsendorj, DT Fuchs… - Frontiers in …, 2021 - frontiersin.org
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

[HTML][HTML] Comparative analysis of aducanumab, zagotenemab and pioglitazone as targeted treatment strategies for Alzheimer's disease

M Abyadeh, V Gupta, V Gupta, N Chitranshi… - Aging and …, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the leading cause of dementia that has remained a major
medical, sociocultural and economical challenge globally. Previously developed treatments …

Reactive astrocytes as treatment targets in Alzheimer's disease—systematic review of studies using the APPswePS1dE9 mouse model

T Smit, NAC Deshayes, DR Borchelt, W Kamphuis… - Glia, 2021 - Wiley Online Library
Astrocytes regulate synaptic communication and are essential for proper brain functioning.
In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an …

Glatiramer acetate immunomodulation: evidence of neuroprotection and cognitive preservation

A Kasindi, DT Fuchs, Y Koronyo, A Rentsendorj… - Cells, 2022 - mdpi.com
Novel, neuroprotective uses of Copaxone (generic name: glatiramer acetate—GA) are being
examined, primarily in neurological conditions involving cognitive decline. GA is a well …

Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications

L Wang, X Mao - International journal of molecular sciences, 2021 - mdpi.com
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Retinal imaging and Alzheimer's disease: a future powered by Artificial Intelligence

H Ashayeri, A Jafarizadeh, M Yousefi, F Farhadi… - Graefe's Archive for …, 2024 - Springer
Alzheimer's disease (AD) is a neurodegenerative condition that primarily affects brain tissue.
Because the retina and brain share the same embryonic origin, visual deficits have been …

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease

H Shi, Y Koronyo, DT Fuchs, J Sheyn… - Acta Neuropathologica …, 2020 - Springer
Extensive effort has been made studying retinal pathology in Alzheimer's disease (AD) to
improve early noninvasive diagnosis and treatment. Particularly relevant are vascular …

T cell-mediated autoimmunity in glaucoma neurodegeneration

L Wang, X Wei - Frontiers in Immunology, 2021 - frontiersin.org
Glaucoma as the leading neurodegenerative disease leads to blindness in 3.6 million
people aged 50 years and older worldwide. For many decades, glaucoma therapy has …

Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

J Alber, F Bouwman, J den Haan… - Alzheimer's & …, 2024 - Wiley Online Library
There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …