Rigidity and flexibility: Unraveling the role of fulvic acid in uranyl sorption on graphene oxide using molecular dynamics simulations

T Lan, P Wu, X Yin, Y Zhao, J Liao… - … Science & Technology, 2023 - ACS Publications
Using molecular dynamics simulations, this work targets a molecular understanding on the
rigidity and flexibility of fulvic acid (FA) in uranyl sorption on graphene oxide (GO). The …

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

A Dominguez-Meijide, E Vasili, A König… - Scientific reports, 2020 - nature.com
Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative
disorders of the elderly and, therefore, affect a growing number of patients worldwide. Both …

Disease‐Modifying Anti‐Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with β‐Amyloid Aggregation

S Brogi, S Butini, S Maramai, R Colombo… - CNS neuroscience & …, 2014 - Wiley Online Library
Aims We recently described multifunctional tools (2a–c) as potent inhibitors of human
Cholinesterases (ChEs) also able to modulate events correlated with Aβ aggregation. We …

Synthesis and evaluation of 7, 8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease

Y He, PF Yao, S Chen, Z Huang, SL Huang… - European Journal of …, 2013 - Elsevier
A series of 7, 8-dehydrorutaecarpine derivatives were synthesized and characterized as
potential multifunctional agents for treatment of Alzheimer's disease (AD). All of these …

Molecular insight into amyloid oligomer destabilizing mechanism of flavonoid derivative 2-(4′ benzyloxyphenyl)-3-hydroxy-chromen-4-one through docking and …

A Kumar, S Srivastava, S Tripathi… - Journal of …, 2016 - Taylor & Francis
Aggregation of amyloid peptide (Aβ) has been shown to be directly related to progression of
Alzheimer's disease (AD). Aβ is neurotoxic and its deposition and aggregation ultimately …

Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33#

M Huang, J Li, L Liu, S Yin, J Wang, Y Lin - Marine drugs, 2016 - mdpi.com
Four new chromone derivatives, phomopsichins A–D (1–4), along with a known compound,
phomoxanthone A (5), were isolated from the fermentation products of mangrove endophytic …

Fulvic acid–a small but powerful natural substance for agricultural and medical applications

DH Goenadi - Menara Perkebunan, 2021 - mp.iribb.org
Humic substances are defined as the result of the decomposition of any organic matter, and
they consist mainly of humin, humic, and fulvic acids. Compared to humin, humic acids and …

A comprehensive toxicological assessment of fulvic acid

C Dai, X Xiao, Y Yuan, G Sharma… - … and Alternative Medicine, 2020 - Wiley Online Library
Fulvic acid (FA), a humic substance, has several nutraceutical properties, including anti‐
inflammation, antimicrobial, and immune regulation abilities. However, systematic safety …

Interaction between shrimp and white spot syndrome virus through PmRab7-VP28 complex: an insight using simulation and docking studies

AK Verma, S Gupta, S Verma, A Mishra… - Journal of molecular …, 2013 - Springer
White spot disease is a devastating disease of shrimp Penaeus monodon in which the
shrimp receptor protein PmRab7 interacts with viral envelop protein VP28 to form PmRab7 …

Insight into conformational change for 14-3-3σ protein by molecular dynamics simulation

G Hu, H Li, JY Liu, J Wang - International Journal of Molecular Sciences, 2014 - mdpi.com
14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that has a double-
edged sword role in human cancers. Former reports have indicated that the 14-3-3 protein …