Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors
morphologically resemble embryonic kidneys with a disrupted architecture and are …

Irreversible end-stage organ failure represents one of the leading causes of death, and
organ transplantation is currently the only curative solution. Donor organ shortage and …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease
modeling and the generation of tissue for renal replacement. Long-term application …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …

The kidney has a tremendous capacity to regenerate following injury, but factors that govern
this response are still largely unknown. We isolated cells from mouse kidneys with high …

Recent studies using human pluripotent stem cells (hPSCs) have developed protocols to
induce kidney-lineage cells and reconstruct kidney organoids. However, the separate …

Acute kidney injury (AKI) is defined as a rapid loss of renal function resulting from various
etiologies, with a mortality rate exceeding 60% among intensive care patients. Because …

Background Although coronavirus disease 2019 (COVID-19) causes significan t morbidity,
mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts …