Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Metal complexes in cancer therapy–an update from drug design perspective

U Ndagi, N Mhlongo, ME Soliman - Drug design, development and …, 2017 - Taylor & Francis
In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …

Gold-based medicine: a paradigm shift in anti-cancer therapy?

CI Yeo, KK Ooi, ERT Tiekink - Molecules, 2018 - mdpi.com
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

New insights in Au-NHCs complexes as anticancer agents

M Porchia, M Pellei, M Marinelli, F Tisato… - European journal of …, 2018 - Elsevier
Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …

Advances in alkynyl gold complexes for use as potential anticancer agents

Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …

Medicinal importance, coordination chemistry with selected metals (Cu, Ag, Au) and chemosensing of thiourea derivatives. A review

E Khan, S Khan, Z Gul… - Critical Reviews in …, 2021 - Taylor & Francis
Thiourea and its derivatives are versatile compounds used in several fields of life ranging
from medicinal to chemosensor applications. In this review article, generally used …

From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases

J Ceramella, A Mariconda, D Iacopetta… - Bioorganic & Medicinal …, 2020 - Elsevier
Cancer is a complex issue and, even though the prevention basics and therapy have been
implemented, it is still the second leading death cause worldwide. With the hope to discover …

[HTML][HTML] Anticancer activity of Metallodrugs and metallizing host defense peptides—current developments in Structure-Activity relationship

CMC Andrés, JM Pérez de la Lastra… - International Journal of …, 2024 - mdpi.com
This article provides an overview of the development, structure and activity of various metal
complexes with anti-cancer activity. Chemical researchers continue to work on the …

Therapeutic potential of dithiocarbamate supported gold compounds

CK Adokoh - RSC advances, 2020 - pubs.rsc.org
Chrysotherapy or aurotherapy, the use of gold as medicine, is two thousand years old.
Hitherto, numerous diverse gold stabilizing ligands for instance vitamins, pyridine …