The regulation and function of lactate dehydrogenase a: therapeutic potential in brain tumor

CJ Valvona, HL Fillmore, PB Nunn… - Brain …, 2016 - Wiley Online Library
There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …

Role of mitochondrial membrane potential and lactate dehydrogenase a in apoptosis

S Zaib, A Hayyat, N Ali, A Gul… - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
Apoptosis is a programmed cell death that occurs due to the production of several catabolic
enzymes. During this process, several morphological and biochemical changes occur in …

Site-specific solvation of the photoexcited protochlorophyllide a in methanol: formation of the hydrogen-bonded intermediate state induced by hydrogen-bond …

GJ Zhao, KL Han - Biophysical journal, 2008 - cell.com
The site-specific solvation of the photoexcited protochlorophyllide a (Pchlide a) in methanol
solvent was investigated using the time-dependent density functional theory method for the …

Protein dynamics and enzymatic catalysis

SD Schwartz - The Journal of Physical Chemistry B, 2023 - ACS Publications
This Perspective presents a review of our work and that of others in the highly controversial
topic of the coupling of protein dynamics to reaction in enzymes. We have been involved in …

Lactate detection sensors for food, clinical and biological applications: A review

G Rattu, N Khansili, VK Maurya, PM Krishna - Environmental Chemistry …, 2021 - Springer
Abstract l-lactate is a major analyte in the food industry, bioprocess engineering, sports
medicine and clinical care unit. l-lactate detection by standard analytical techniques is …

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

EJ De Genst, T Guilliams, J Wellens, EM O'day… - Journal of molecular …, 2010 - Elsevier
The aggregation of the intrinsically disordered protein α-synuclein to form fibrillar amyloid
structures is intimately associated with a variety of neurological disorders, most notably …

The nanoparticle-Protein Corona untold history (1907–2007)

E Casals, M Vitali, V Puntes - Nano Today, 2024 - Elsevier
The adsorption of biomolecules, primarily proteins, on the surfaces of nanoparticles plays a
crucial role in elucidating the safe application of nanotechnology, especially in medicine …

Promoting vibrations and the function of enzymes. Emerging theoretical and experimental convergence

VL Schramm, SD Schwartz - Biochemistry, 2018 - ACS Publications
A complete understanding of enzyme catalysis requires knowledge of both transition state
features and the detailed motions of atoms that cause reactant molecules to form and …

Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments

N Coquelle, E Fioravanti, M Weik, F Vellieux… - Journal of Molecular …, 2007 - Elsevier
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate with
concomitant oxidation of NADH during the last step in anaerobic glycolysis. In the present …

Deciphering evolutionary trajectories of lactate dehydrogenases provides new insights into allostery

AY Robin, C Brochier-Armanet… - Molecular Biology …, 2023 - academic.oup.com
Abstract Lactate dehydrogenase (LDH, EC. 1.1. 127) is an important enzyme engaged in the
anaerobic metabolism of cells, catalyzing the conversion of pyruvate to lactate and NADH to …