Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease
characterized by insulin resistance and β cell failure leading to elevated blood glucose …

Advanced glycation endproducts (AGEs) form by Maillard-reactions after initial binding of
aldehydes with amines or amides in heated foods or in living organisms. The mechanisms of …

Despite new and effective drug therapies, insulin resistance (IR), type 2 diabetes mellitus
(T2D) and its complications remain major medical challenges. It is accepted that IR, often …

Advanced glycation end products (AGEs) are a heterogeneous group of molecules
produced, non‐enzymatically, from the interaction between reducing sugars and the free …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The epidemics of insulin resistance (IR) and type 2 diabetes (T2D) affect the first world as
well as less-developed countries, and now affect children as well. Persistently elevated …

OBJECTIVE Increased oxidative stress (OS) and impaired anti-OS defenses are important in
the development and persistence of insulin resistance (IR). Several anti-inflammatory and …

Persistently elevated oxidative stress and inflammation precede or occur during the
development of type 1 or type 2 diabetes mellitus and precipitate devastating complications …

A non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins,
lipids and nucleic acids contributes to the aging of macromolecules and to the development …

Arterial aging is the major contributing factor to increases in the incidence and prevalence of
cardiovascular disease, due mainly to the presence of chronic, low-grade,'sterile'arterial …