In the late 70's, the discovery of the restriction enzymes made possible the biological
production of functional proteins by recombinant DNA technologies, a fact that largely …

Fundamental clinical areas such as drug delivery and regenerative medicine require
biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers …

Hexahistidine-tagged proteins can be clustered by divalent cations into self-containing,
dynamic protein depots at the microscale, which under physiological conditions leak …

Among bio-inspired protein materials, secretory protein microparticles are of clinical interest
as self-contained, slow protein delivery platforms that mimic secretory granules of the human …

We have developed a simple, robust, and fully transversal approach for the a-la-carte
fabrication of functional multimeric nanoparticles with potential biomedical applications …

Multiple advanced formulations and drug delivery systems (DDSs) have been developed to
deliver protein-based biotherapeutics via the subcutaneous (SC) route. These …

By following simple protein engineering steps, recombinant proteins with promising
applications in the field of drug delivery can be assembled in the form of functional materials …

The sustained release of small, tumor-targeted cytotoxic drugs is an unmet need in cancer
therapies, which usually rely on punctual administration regimens of non-targeted drugs …

Through the controlled addition of divalent cations, polyhistidine-tagged proteins can be
clustered in form of chemically pure and mechanically stable micron-scale particles. Under …

Protein materials are versatile tools in diverse biomedical fields. Among them, artificial
secretory granules (SGs), mimicking those from the endocrine system, act as mechanically …