Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …

G protein-coupled receptors (GPCRs) are important drug targets that mediate various
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …

The discovery of receptor-receptor interactions (RRI) has expanded our understanding of
the role that G protein-coupled receptors (GPCRs) play in intercellular communication. The …

The concept of allosteric receptor–receptor interactions in G protein-coupled receptor homo-
and heteroreceptor complexes in which they physically interact provides a new dimension to …

G protein-coupled receptors (GPCRs) not only exist as monomers but also as homomers
and heteromers in which allosteric receptor-receptor interactions take place, modulating the …

Depression and schizophrenia are two highly prevalent and severely debilitating
neuropsychiatric disorders. Both conventional antidepressant and antipsychotic …

Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …