Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7)(also referred to as FBW7 or
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …

Non-small cell lung cancers (NSCLCs) represent 85% of lung tumors. NSCLCs encompass
multiple cancer types, such as adenocarcinomas (LUADs), squamous cell cancers (LUSCs) …

As one of the most common forms of cancer, lung cancers present as a collection of different
histological subtypes. These subtypes are characterized by distinct sets of driver mutations …

Oxaliplatin is the first-line regime for advanced gastric cancer treatment, while its resistance
is a major problem that leads to the failure of clinical treatments. Tumor cell heterogeneity …

Background: There is increasing evidence that tumour-associated macrophages (TAMs) are
critical in the formation of lung metastases. However, the molecular mechanisms of tumour …

Ubiquitination of proteins is a sophisticated post-translational modification implicated in the
regulation of an ever-growing abundance of cellular processes. Recent insights into different …

Many cancer therapies aim to trigger apoptosis in cancer cells. Nevertheless, the presence
of oncogenic alterations in these cells and distorted composition of tumour …

Post-translational modification of proteins with ubiquitin (ubiquitination) provides a rapid and
versatile mechanism for regulating cellular signalling systems. Met1-linked (or 'linear') …

Lung squamous cell carcinoma (LUSC) represents a major subtype of non-small cell lung
cancer with limited treatment options. Previous studies have elucidated the complex genetic …

X-ray computed tomography is a reliable technique for the detection and longitudinal
monitoring of pulmonary nodules. In preclinical stages of diagnostic or therapeutic …