The immune system responds to cancer in two main ways. First, there are prewired
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …

Regulatory T cells (Tregs) are key immunosuppressive cells that promote tumor growth by
hindering the effector immune response. Tregs utilize multiple suppressive mechanisms to …

Abstract The programmed death (PD)‐1/PD‐ligand (PD‐L) pathway and regulatory T cells
(Tregs) are essential for the maintenance of immune tolerance. Their activation in the tumour …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

A tumour microenvironment abundant in regulatory T (Treg) cells aids solid tumours to
evade clearance by effector T cells. Systemic strategies to suppress Treg cells or to augment …

Single-cell RNA sequencing (scRNAseq) of tumour-infiltrating immune cells in high-grade
serous ovarian cancer (HGSOC) omental biopsies reveals potential targets that could …

Breast cancer development and progression rely not only on the proliferation of neoplastic
cells but also on the significant heterogeneity in the surrounding tumor microenvironment. Its …

CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the
regulation of CD4 tumor-specific T (T TS) cells is unclear. We demonstrate that CD4 T TS …

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a cell surface
receptor, is expressed on normal epithelial tissue and highly expressed in cancers of high …

CD4+ T cells are crucial in generating and sustaining immune responses. They orchestrate
and fine-tune mammalian innate and adaptive immunity through cell-based interactions and …