The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) isoenzymes are
responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors into Δ4 …

Selection of a dominant follicle, capable of ovulating, from among a cohort of similarly sized
follicles is a critical transition in follicular development. The mechanisms that regulate the …

Oestrogens are pivotal in ovarian follicular growth, development and function, with
fundamental roles in steroidogenesis, nurturing the oocyte and ovulation. Infections with …

Survival and inhibitory factors regulate steroidogenesis and determine the fate of developing
follicles. The objective of this study was to determine the role of transforming growth factor …

The objectives of this study were to develop a serum-free bovine granulosa cell culture
system in which FSH-responsive estradiol production could be induced and maintained, and …

Folliculogenesis is associated with the development of a group of follicles at various stages
of maturation from which a species-specific number of follicles are selected for continued …

Locally produced growth factors may have important modulatory roles in final ovarian
follicular growth. The aim of this study was to investigate the possible participation of …

Mechanisms that allow selection of a dominant ovarian follicle from a cohort of growing
follicles are unknown. Large healthy, estrogen-active follicles contain more LH receptors …

Problem Pelvic inflammatory disease and metritis are important causes of infertility in
humans and domestic animals. Uterine infection with Escherichia coli in cattle is associated …

A novel experimental model was developed in cattle to investigate the requirement for FSH
and LH during ovarian follicle growth and development. On Day 5 of the estrous cycle, 7 …