Levosimendan is a positive inotrope with vasodilating properties (inodilator) indicated for
decompensated heart failure (HF) patients with low cardiac output. Accumulated evidence …

Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients
incapable of adequately ventilating and/or oxygenating due to respiratory or other disease …

Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident:
it prolongs ventilator dependency and increases morbidity, duration of hospital stay, and …

Mechanical ventilation is an essential intervention for intensive care unit patients with acute
lung injury. However, the use of controlled mechanical ventilation in both animal and human …

Current animal models of sepsis often incorporate antibiotics to be consistent with clinical
standards for treatment of patients in the intensive care unit. However, such experimental …

Background Sepsis is a leading cause of death in China, the mortality rate of which is
elevated when cardiac dysfunction is induced. Levosimendan is used for the treatment of …

目的分析过度镇静对重症加强治疗病房(ICU) 机械通气患者预后的影响. 方法回顾性分析2009
年1 月至2014 年11 月入住安徽省六安市人民医院重症医学科214 例行机械通气成人患者的 …

Background and Aims. Myocyte apoptosis plays a critical role in the development of
doxorubicin‐(DOX‐) induced cardiotoxicity. In addition to its cardiotonic effect, laboratory …

Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors,
and calcium sensitizers, which have been successively discovered and applied in clinical …

Levosimendan is a calcium sensitizer that promotes myocyte contractility through its calcium-
dependent interaction with cardiac troponin C. Administered intravenously, it has been used …