A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …

Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

INTRODUCTION A disease is rarely a straightforward consequence of an abnormality in a
single gene, but rather reflects the interplay of multiple molecular processes. The …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

In a research environment dominated by reductionist approaches to brain disease
mechanisms, gene network analysis provides a complementary framework in which to tackle …

Alzheimer's disease (AD) is one of the most complicated progressive neurodegeneration
diseases that involve many genes, proteins, and their complex interactions. No effective …

In the mammalian cortex, neurons and glia form a patterned structure across six layers
whose complex cytoarchitectonic arrangement is likely to contribute to cognition. We …

Contemporary views of human disease are based on simple correlation between clinical
syndromes and pathological analysis dating from the late 19th century. Although this …

背景1 型糖尿病(T1D) 是一种自身免疫性疾病, 其特征是胰腺β 细胞被浸润的免疫细胞所破坏.
有观点认为在T1D 的进展过程中胰岛β 细胞与免疫细胞具有双向的协同作用 …