Cyclin D1, cancer progression, and opportunities in cancer treatment
Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …
An overview of the Nrf2/ARE pathway and its role in neurodegenerative diseases
E Zgorzynska, B Dziedzic, A Walczewska - International Journal of …, 2021 - mdpi.com
Nrf2 is a basic region leucine-zipper transcription factor that plays a pivotal role in the
coordinated gene expression of antioxidant and detoxifying enzymes, promoting cell …
coordinated gene expression of antioxidant and detoxifying enzymes, promoting cell …
Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer
MF Xia, YZ Zhang, K Jin, ZT Lu, Z Zeng, W Xiong - Cell & bioscience, 2019 - Springer
Mitochondria are energy factories of cells and are important pivots for intracellular
interactions with other organelles. They interact with the endoplasmic reticulum …
interactions with other organelles. They interact with the endoplasmic reticulum …
Conservation of the Keap1-Nrf2 system: an evolutionary journey through stressful space and time
Y Fuse, M Kobayashi - Molecules, 2017 - mdpi.com
The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against
oxidative and xenobiotic stress. Its regulatory mechanisms, eg, stress-sensing mechanism …
oxidative and xenobiotic stress. Its regulatory mechanisms, eg, stress-sensing mechanism …
Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity
Y Zhang, Y Xiang - Biochemical Journal, 2016 - portlandpress.com
The consensus cis-regulatory AP-1 (activator protein-1)-like AREs (antioxidant-response
elements) and/or EpREs (electrophile-response elements) allow for differential recruitment …
elements) and/or EpREs (electrophile-response elements) allow for differential recruitment …
Redox functions of heme oxygenase-1 and biliverdin reductase in diabetes
L Rochette, M Zeller, Y Cottin, C Vergely - Trends in Endocrinology & …, 2018 - cell.com
In patients with diabetes, the hyperglycemia-driven excess generation of reactive oxygen
species (ROS) induces oxidative stress (OS) in a variety of tissues. OS is closely associated …
species (ROS) induces oxidative stress (OS) in a variety of tissues. OS is closely associated …
[HTML][HTML] Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells
The nuclear factor (erythroid 2)-like (NRF) transcription factors are a subset of cap'n'collar
transcriptional regulators. They consist of three members, NRF1, NRF2, and NRF3, that …
transcriptional regulators. They consist of three members, NRF1, NRF2, and NRF3, that …
Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation
AMMA Chowdhury, H Katoh, A Hatanaka, H Iwanari… - Scientific reports, 2017 - nature.com
Accumulated evidence suggests a physiological relationship between the transcription
factor NRF3 (NFE2L3) and cancers. Under physiological conditions, NRF3 is repressed by …
factor NRF3 (NFE2L3) and cancers. Under physiological conditions, NRF3 is repressed by …
Binding partners of NRF2: Functions and regulatory mechanisms
LB Nam, YS Keum - Archives of biochemistry and biophysics, 2019 - Elsevier
NRF2 is a redox-sensitive transcription factor that plays an important role in protecting
organisms against diverse types of electrophiles or oxidants. The level of NRF2 is …
organisms against diverse types of electrophiles or oxidants. The level of NRF2 is …
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease
JC Villaescusa, B Li, EM Toledo… - The EMBO …, 2016 - embopress.org
Pre‐B‐cell leukemia homeobox (PBX) transcription factors are known to regulate
organogenesis, but their molecular targets and function in midbrain dopaminergic neurons …
organogenesis, but their molecular targets and function in midbrain dopaminergic neurons …