Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) contain abundant
CD8+ tumor-infiltrating lymphocytes (TILs) responding to the abundant neoantigens from …

Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to
cause more than 50 diseases,. However, repeat expansions are often not explored beyond …

Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …

Using CRISPR-Cas9 nicking enzymes, we examined the interaction between the replication
machinery and single-strand breaks, one of the most common forms of endogenous DNA …

Expansions of gene-specific DNA tandem repeats (TRs), first described in 1991 as a
disease-causing mutation in humans, are now known to cause> 60 phenotypes, not just …

Epstein–Barr virus (EBV) is an oncogenic herpesvirus associated with several cancers of
lymphocytic and epithelial origin,–. EBV encodes EBNA1, which binds to a cluster of 20 …

In this era of precision medicine, with the help of biomarkers, immunotherapy has
significantly improved prognosis of many patients with malignant tumor. Deficient mismatch …

Mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) represents a
distinct phenotype among solid tumors characterized by frequent frameshift mutations …