The skeleton is an organ of dual functionality; on the one hand, it provides protection and
structural competence. On the other hand, it participates extensively in coordinating …

Актуальность: Остеопороз является важной медицинской и социальной проблемой
общественного здравоохранения в стареющем или пожилом обществе. Остеопороз …

Osteoporosis is the most common bone disorder, which is a highly dangerous condition that
can promote bone metastases. As the current treatment for osteoporosis involves long-term …

Glucocorticoid-induced osteoporosis (GIOP) lacks fully effective treatments. This study
investigated the role of Piezo1, a mechanosensitive ion channel component 1, in GIOP. We …

Osteocytes are the major actors in bone mechanobiology. Within bone matrix, they are
trapped close together in a submicrometric interconnected network: the lacunocanalicular …

Background Active vitamin D analog eldecalcitol is clinically applied in treatment of
postmenopausal osteoporosis. This study aims to determine the role of eldecalcitol in the …

Osteocytes, the most abundant bone cells, form an extensive cellular network via
interconnecting dendrites. Like neurons in the brain, the long‐lived osteocytes perceive …

Abstract Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene mutations lead to fragile X
syndrome, cognitive disorders, and, in some individuals, scoliosis and craniofacial …

摘要背景: 骨质疏松导致的脆性骨折发病率逐年上升, 亟需探索其病理生理, 潜在生物标志物,
治疗靶点及有效药物. 骨微环境中存在多种细胞, 对骨代谢的维持至关重要. 近几年, 单细胞RNA …

Osteocyte dendrites extend great distances through canaliculi in bone supported by an
extensive cytoskeletal network. The formation and maintenance of osteocyte dendrites is …