OAT, OATP, and MRP drug transporters and the remote sensing and signaling theory
SK Nigam, JC Granados - Annual review of pharmacology and …, 2023 - annualreviews.org
The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …
What if not all metabolites from the uremic toxin generating pathways are toxic? A hypothesis
R Vanholder, SK Nigam, S Burtey, G Glorieux - Toxins, 2022 - mdpi.com
The topic of uremic toxicity has received broad attention from the nephrological community
over the past few decades. An aspect that is much less often considered is the possibility …
over the past few decades. An aspect that is much less often considered is the possibility …
VARIDT 2.0: structural variability of drug transporter
The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …
medicine and rational drug use. However, these valuable data are not sufficiently covered …
Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions
N Jamshidi, SK Nigam - Scientific reports, 2022 - nature.com
In vitro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6,
NKT) and OAT3 (SLC22A8) among the main multi-specific “drug” transporters. They also …
NKT) and OAT3 (SLC22A8) among the main multi-specific “drug” transporters. They also …
Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies
The human solute carrier 22A (SLC22A) family consists of 23 members, representing one of
the largest families in the human SLC superfamily. Despite their pharmacological and …
the largest families in the human SLC superfamily. Despite their pharmacological and …
Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3
How organs sense circulating metabolites is a key question. Here, we show that the
multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3 …
multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3 …
A key role for the transporter OAT1 in systemic lipid metabolism
Organic anion transporter 1 (OAT1/SLC22A6) is a drug transporter with numerous
xenobiotic and endogenous substrates. The Remote Sensing and Signaling Theory …
xenobiotic and endogenous substrates. The Remote Sensing and Signaling Theory …
Renal and non-renal response of ABC and SLC transporters in chronic kidney disease
Introduction The solute carrier (SLC) and the ATP-binding cassette (ABC) transporter
superfamilies play essential roles in the disposition of small molecules (endogenous …
superfamilies play essential roles in the disposition of small molecules (endogenous …
A carnitine transporter at the blood–brain barrier modulates sleep via glial lipid metabolism in Drosophila
A Avila, AS Lewandowski, Y Li, J Gui, KA Lee… - Proceedings of the …, 2025 - pnas.org
To regulate brain function, peripheral compounds must traverse the blood–brain barrier
(BBB), an interface between the brain and the circulatory system. To determine whether …
(BBB), an interface between the brain and the circulatory system. To determine whether …
[HTML][HTML] Ammonia exposure causes the disruption of the solute carrier family gene network in pigs
C Xia, X Zhang, Y Zhang, J Li, H Xing - Ecotoxicology and Environmental …, 2021 - Elsevier
Ammonia is the main harmful gas in livestock houses. However, the toxic mechanism of
ammonia is still unclear. Therefore, we examined the effects of ammonia exposure on …
ammonia is still unclear. Therefore, we examined the effects of ammonia exposure on …