Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Many vaccines induce protective immunity via antibodies. Systems biology approaches
have been used to determine signatures that can be used to predict vaccine-induced …

Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …

Identification of complex molecular networks underlying common human phenotypes is a
major challenge of modern genetics. In this study, we develop a method for network-based …

Despite advances in high-throughput sequencing that have revolutionized the discovery of
gene defects in rare Mendelian diseases, there are still gaps in translating individual …

Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …

Haploinsufficiency, wherein a single functional copy of a gene is insufficient to maintain
normal function, is a major cause of dominant disease. Human disease studies have …

The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

Deciphering the genetic basis of human diseases is an important goal of biomedical
research. On the basis of the assumption that phenotypically similar diseases are caused by …