Sophorolipids: Anti-cancer activities and mechanisms

RT Miceli, DT Corr, M Barroso, N Dogra… - Bioorganic & Medicinal …, 2022 - Elsevier
Sophorolipids (SLs) are biosurfactants synthesized as secondary metabolites by non-
pathogenic yeasts and other microorganisms. They are members of glycolipid microbial …

Flow cytometry in the diagnosis of canine B-cell lymphoma

F Riondato, S Comazzi - Frontiers in Veterinary Science, 2021 - frontiersin.org
B cell lymphoma (BCL) is a heterogeneous group of lymphoid malignancies which comprise
the majority of canine lymphomas. Diffuse large B cell lymphoma is the most common …

Chalcone methoxy derivatives exhibit antiproliferative and proapoptotic activity on canine lymphoma and leukemia cells

A Pawlak, M Henklewska, B Hernandez Suarez… - Molecules, 2020 - mdpi.com
Chalcones are interesting candidates for anti-cancer drugs due to the ease of their synthesis
and their extensive biological activity. The study presents antitumor activity of newly …

The Effect of Xanthohumol Derivatives on Apoptosis Induction in Canine Lymphoma and Leukemia Cell Lines

M Grudzień, A Pawlak, T Tronina, J Kutkowska… - International Journal of …, 2023 - mdpi.com
Xanthohumol is a cancer chemopreventive agent that can interfere with the initiation,
promotion, and progression phase of carcinogenesis via a variety of inhibitory mechanisms …

Benzyl isothiocyanate, a vegetable-derived compound, induces apoptosis via ROS accumulation and DNA damage in canine lymphoma and leukemia cells

M Henklewska, A Pawlak, RF Li, J Yi, I Zbyryt… - International Journal of …, 2021 - mdpi.com
Treatment of neoplastic diseases in companion animals is one of the most important
problems of modern veterinary medicine. Given the growing interest in substances of natural …

Synthesis and Antiproliferative Effect of Ethyl 4‐[4‐(4‐Substituted Piperidin‐1‐yl)]benzylpyrrolo[1,2‐a]quinoxalinecarboxylate Derivatives on Human Leukemia Cells

V Desplat, M Vincenzi, R Lucas, S Moreau… - …, 2017 - Wiley Online Library
Acute leukemia is a hematological malignancy with high incidence and recurrence rates and
is characterized by an accumulation of blasts in bone marrow due to proliferation of …

Mechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology

R Klopfleisch, B Kohn, AD Gruber - The Veterinary Journal, 2016 - Elsevier
Several classes of chemotherapy drugs are used as first line or adjuvant treatment of the
majority of tumour types in veterinary oncology. However, some types of tumour are …

Pharmacokinetics of a cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown aetiology

HA Levitin, KD Foss, Z Li, JM Reinhart… - Journal of Veterinary …, 2021 - Wiley Online Library
Cytosine arabinoside (CA) is a commonly used treatment for dogs with
meningoencephalomyelitis of unknown aetiology (MUE) with various proposed protocols …

A novel canine B‐cell leukaemia cell line. Establishment, characterisation and sensitivity to chemotherapeutics

A Pawlak, E Ziolo, J Kutkowska… - Veterinary and …, 2017 - Wiley Online Library
We established a new B‐cell leukaemia cell line CLB70 from a dog with chronic lymphocytic
leukaemia. This cell line is positive for CD20, CD45, CD79a, MHC class II, IgG, IgM; weakly …

Oral cytarabine ocfosfate pharmacokinetics and assessment of leukocyte biomarkers in normal dogs

DM Zwueste, KM Vernau, W Vernau… - Journal of Veterinary …, 2023 - Wiley Online Library
Abstract Background Cytosine arabinoside (Ara‐C) is a nucleoside analog prodrug utilized
for immunomodulatory effects mediated by its active metabolite Ara‐CTP. Optimal dosing …