Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies

BB Aggarwal, A Bhardwaj, RS Aggarwal… - Anticancer …, 2004 - ar.iiarjournals.org
Resveratrol, trans-3, 5, 4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the
roots of white hellebore (Veratrum grandiflorum O. Loes), but has since been found in …

Resveratrol: a review of preclinical studies for human cancer prevention

M Athar, JH Back, X Tang, KH Kim, L Kopelovich… - Toxicology and applied …, 2007 - Elsevier
The search for novel and effective cancer chemopreventive agents has led to the
identification of various naturally occurring compounds one of which is resveratrol (trans-3 …

Cancer chemoprevention through dietary antioxidants: progress and promise

N Khan, F Afaq, H Mukhtar - Antioxidants & redox signaling, 2008 - liebertpub.com
It is estimated that nearly one-third of all cancer deaths in the United States could be
prevented through appropriate dietary modification. Various dietary antioxidants have …

Resveratrol modulates drug-and carcinogen-metabolizing enzymes in a healthy volunteer study

HHS Chow, LL Garland, CH Hsu, DR Vining… - Cancer prevention …, 2010 - AACR
Resveratrol has been shown to exhibit cancer-preventive activities in preclinical studies. We
conducted a clinical study to determine the effect of pharmacologic doses of resveratrol on …

Suppression of 7,12-Dimethylbenz(a)anthracene-induced Mammary Carcinogenesis in Rats by Resveratrol: Role of Nuclear Factor-κB, Cyclooxygenase 2, and …

S Banerjee, C Bueso-Ramos, BB Aggarwal - Cancer research, 2002 - AACR
We have reported recently that resveratrol (trans-3, 4′, 5-trihydroxystilbene), a polyphenolic
phytoalexin found in grapes, fruits, and root extracts of the weed Polygonum cuspidatum, is …

Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer

D Delmas, A Lançon, D Colin, B Jannin… - Current drug …, 2006 - ingentaconnect.com
Resveratrol (3, 4', 5 tri-hydroxystilbene) is a phytoalexin produced in hudge amount in
grapevine skin in response to infection by Bothrytis cinerea. This production of resveratrol …

The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1

GA Potter, LH Patterson, E Wanogho, PJ Perry… - British journal of …, 2002 - nature.com
Resveratrol is a cancer preventative agent that is found in red wine. Piceatannol is a closely
related stilbene that has antileukaemic activity and is also a tyrosine kinase inhibitor …

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung

J Hukkanen, O Pelkonen, J Hakkola… - Critical reviews in …, 2002 - Taylor & Francis
Pathogenesis of lung diseases, such as lung cancer and chronic obstructive pulmonary
disease, is tightly linked to exposure to environmental chemicals, most notably tobacco …

Cytochrome P450 gene polymorphism and cancer

JAG Agúndez - Current drug metabolism, 2004 - ingentaconnect.com
Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and
environmental chemicals. Several CYP enzymes metabolically activate procarcinogens to …

Resveratrol's anti-cancer effects through the modulation of tumor glucose metabolism

A Brockmueller, S Sameri, A Liskova, K Zhai… - Cancers, 2021 - mdpi.com
Simple Summary The prevention and treatment of cancer is an ongoing medical challenge.
In the context of personalized medicine, the well-studied polyphenol resveratrol could …