Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Membrane-less organelles are cellular structures which arise through the phenomenon of
phase separation. This process enables compartmentalization of specific sets of …

Rapidly progressive Alzheimer's disease (rpAD) is a particularly aggressive form of
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …

Introduction We investigated the proteomic profiles of amyloid plaques (APs) from
Alzheimer's disease (AD) and age-matched non-AD brains and APP/PS1 transgenic model …

The amyloid cascade hypothesis of Alzheimer's disease (AD) proposes amyloid-β (Aβ) is a
chief pathological element of dementia. AD therapies have targeted monomeric and …

Complex intercellular interactions as well as biomolecular and biomechanical cues from the
extracellular matrix (ECM) profoundly affect cellular functions. Traditional transcriptomic and …

Synaptic loss is the best correlate of cognitive deficits in Alzheimer's disease (AD). Extensive
experimental evidence also indicates alterations of synaptic properties at the early stages of …

Multiple applications of proteomics in life and health science, pathology and pharmacology,
require handling size‐limited cell and tissue samples. During proteomic sample preparation …

The human body comprises rich populations of cells, which are arranged into tissues and
organs with diverse functionalities. These cells exhibit a broad spectrum of phenotypes and …

Background Haematoxylin and eosin (H&E)—which respectively stain nuclei blue and other
cellular and stromal material pink—are routinely used for clinical diagnosis based on the …