For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …

ABSTRACT PSI-7977, a prodrug of 2′-F-2′-C-methyluridine monophosphate, is the
purified diastereoisomer of PSI-7851 and is currently being investigated in phase 3 clinical …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

Viruses have been recognized as the etiological agents responsible for many pathological
conditions ranging from asymptomatic infections to serious diseases, even leading to death …

Stereochemistry is one of the essential dimensions in pharmacology as it dictates how
enantiomers interact with biological systems. Chirality is very important in drug design …

Although 2′-deoxy-2′-α-F-2′-β-C-methyl (2′-F/Me) uridine nucleoside derivatives are a
successful class of antiviral drugs, this modification had not been studied in …

The direct-acting antivirals (DAAs) currently in development for treatment of hepatitis C fall
into four categories:(i) NS3/4A protease inhibitors: ABT-450/r, faldaprevir, asunaprevir, GS …

Ribonucleotide analog inhibitors of the RNA-dependent RNA polymerase of hepatitis C
virus (HCV) represent one of the most exciting recent developments in HCV antiviral …

Fluorinated nucleosides are an important class of modified nucleosides that have
demonstrated therapeutic potential for treating various human diseases, especially viral …