The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is
widespread among potentially natural nucleic acid alternatives taken from RNA's close …

Nature relies on large molecules to carry out sophisticated chemical operations, such as
catalysis, tight and specific binding, directed flow of electrons, or controlled crystallization of …

THE ultimate goal of the UN Framework Convention on Climate Change is to achieve"
stabilization of greenhouse-gas concentrations at a level that would prevent dangerous …

The synthesis of modified oligonucleotides by the phosphoramidite approach and their
applications - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

The 2–5A system is an RNA degradation pathway that can be induced by the interferons
(IFNs). Treatment of cells with IFN activates genes encoding several double-stranded RNA …

Abstract “We'll never be able to know” is a truism that leads to resignation with respect to any
experimental effort to search for the chemistry of life's origin. But such resignation runs …

THE concept of an RNA world1, 2 in the chemical origin of life is appealing, as nucleic acids
are capable of both information storage and acting as templates that catalyse the synthesis …

Qualitative conformational analysis of the entirety of conceivable hexo‐and pentopyranosyl
oligonucleotide systems derived from the diastereoisomeric aldohexoses (CH2O) 6 and …

The stabilities of all possible purine/pyrimidine pairings between the isomeric nucleobases
isocytosine (iso-C) and isoguanine (iso-G) and standard genomic bases are reported for two …