The promises and perils of psychedelic pharmacology for psychiatry
TD McClure-Begley, BL Roth - Nature Reviews Drug Discovery, 2022 - nature.com
Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …
Models of psychedelic drug action: modulation of cortical-subcortical circuits
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …
recaptured the imagination of both science and popular culture, and may have efficacy in …
[HTML][HTML] Structure of a hallucinogen-activated Gq-coupled 5-HT2A serotonin receptor
Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl
phenylalkylamines are widely used recreationally with psilocybin being considered as a …
phenylalkylamines are widely used recreationally with psilocybin being considered as a …
Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects
Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric
research and therapy. However, no modern studies have evaluated subjective and …
research and therapy. However, no modern studies have evaluated subjective and …
The entropic brain-revisited
RL Carhart-Harris - Neuropharmacology, 2018 - Elsevier
The entropic brain hypothesis proposes that within upper and lower limits, after which
consciousness may be lost, the entropy of spontaneous brain activity indexes the …
consciousness may be lost, the entropy of spontaneous brain activity indexes the …
Reviewing the potential of psychedelics for the treatment of PTSD
E Krediet, T Bostoen, J Breeksema… - International Journal …, 2020 - academic.oup.com
There are few medications with demonstrated efficacy for the treatment of posttraumatic
stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy …
stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy …
Therapeutic potential of psychedelic drugs: navigating high hopes, strong claims, weak evidence, and big money
K Humphreys, P Todd Korthuis… - Annual Review of …, 2024 - annualreviews.org
Therapeutic claims about many psychedelic drugs have not been evaluated in any studies
of even modest rigor. The science of psychedelic drugs is strengthening however, making it …
of even modest rigor. The science of psychedelic drugs is strengthening however, making it …
[HTML][HTML] Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention
Psychedelic drugs, including the serotonin 2a (5-HT 2A) receptor partial agonist psilocybin,
are receiving renewed attention for their possible efficacy in treating a variety of …
are receiving renewed attention for their possible efficacy in treating a variety of …
Unifying theories of psychedelic drug effects
LR Swanson - Frontiers in pharmacology, 2018 - frontiersin.org
How do psychedelic drugs produce their characteristic range of acute effects in perception,
emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of …
emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of …
[HTML][HTML] Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses
E Drummond, W McCulloch, GM Knudsen… - Neuroscience & …, 2022 - Elsevier
Clinical research into serotonergic psychedelics is expanding rapidly, showing promising
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs …