Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Leishmaniasis is one of the six diseases regarded most neglected by World Health
Organization which is predominant in developing countries. Clinically, among the different …

The protozoan parasite Leishmania is an intracellular pathogen infecting and replicating
inside vertebrate host macrophages. A recent model suggests that promastigote and …

Visceral leishmaniasis (VL), the second-most dreaded parasitic disease after malaria, is
currently endemic in 88 countries. Dramatic increases in the rates of infection, drug …

Aims Recently, strategies of cancer treatment using combination of agents with distinct
molecular mechanism (s) of action are considered more promising due to its high efficacy …

Leishmaniasis consists of a complex spectrum of infectious diseases with worldwide
distribution of which visceral leishmaniasis or kala-azar caused by Leishmania donovani is …

Leishmaniasis is a severe public-health problem, with high rates of morbidity and mortality.
Efforts to find new, effective and safe oral agents for the treatment of leishmaniasis have …

Background Despite advancements in the prognosis and management of breast cancer, it
remains a major cause of mortality in women worldwide. Centchroman (CC), an oral …

Herein, we present biological studies on 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs)
obtained via Biginelli reaction catalyzed by NH4Cl under solvent-free conditions. Until now …

Abstract Pyrido [2, 3‐d] pyrimidine‐2, 4 (1H, 3H)‐diones were synthesized, for the first time,
from indole chalcones and 6‐aminouracil, and their ability to inhibit leishmaniasis and …