Sequence-specific DNA-binding proteins regulate gene expression and also serve structural
and catalytic roles in other cellular processes. How do these proteins bind to double-helical …

Protein-nucleic acid interactions are crucial in the regulation of many fundamental cellular
processes. The nature of these interactions is susceptible to analysis by a variety of …

The gel electrophoresis mobility shift assay (EMSA) is used to detect protein complexes with
nucleic acids. It is the core technology underlying a wide range of qualitative and …

The peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor that has a
pivotal role in adipocyte differentiation and expression of adipocyte-specific genes 1, 3. The …

PPARγ is a member of the PPAR subfamily of nuclear receptors. In this work, the structure of
the human PPARγ cDNA and gene was determined, and its promoters and tissue-specific …

Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of
fibrates, thiazolidinediones and fatty acids, which are known activators (and/or ligands) of …

The toxR gene encodes a transcriptional activator controlling cholera toxin, pllus, and outer-
membrane protein expression in V cholerae. Nucleotide sequence and mutational analysis …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor implicated in
adipocyte differentiation and insulin sensitivity. We investigated whether PPARγ expression …

Using electron microscopy and topological methods, we have deduced an average structure
for negatively supercoiled circular DNA in solution. Our data suggest that DNA has a …

The bending locus of trypanosome kinetoplast DNA, identified by gel electrophoresis, has
tracts of a simple repeat sequence (CA5–6 T) symmetrically distributed about it, with a …