Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …

The tumor microenvironment (TME) provokes endoplasmic reticulum (ER) stress in
malignant cells and infiltrating immune populations. Sensing and responding to ER stress is …

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are
required for the function of STING (TMEM173), an ER-resident transmembrane protein …

Abstract Background Circular RNAs are a subgroup of non-coding RNAs and generated by
a mammalian genome. Herein, the expression and function of circular RNA circ-TTBK2 were …

Cadmium (Cd), an occupational and environmental pollutant, induces nephrotoxicity by
primarily damaging renal proximal tubular cells. In this study, we hypothesized that …

Activation of the ER stress response is associated with malignant progression of B cell
chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER …

Myc activation is a primary oncogenic event in many human cancers; however, these
transcription factors are difficult to inhibit pharmacologically, suggesting that Myc-dependent …

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells, responsible for
protein synthesis, folding, sorting, and transportation. ER stress is initiated when the …

Endoplasmic reticulum (ER) stress is activated in nonalcoholic fatty liver disease (NAFLD),
raising the possibility that ER stress‐dependent metabolic dysfunction, inflammation, and …

The functional status of mitochondria and the endoplasmic reticulum are central to renal
ischemia/reperfusion injury (IRI). X-box binding protein 1 (XBP1) is an important …