IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype

S Domínguez-Zorita, I Romero-Carramiñana… - Cell Death & …, 2023 - nature.com
Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …

Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs

SS Prabhu, AS Nair, SV Nirmala - Archives of Pharmacal Research, 2023 - Springer
The fact that mitochondria play a crucial part in energy generation has led to the nickname
“powerhouses” of the cell being applied to them. They also play a significant role in many …

Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults

WH Lu, S Guyonnet, LO Martinez, A Lucas, A Parini… - GeroScience, 2023 - Springer
Intrinsic capacity (IC), the composite of physical and mental capacities, declines with age at
different rates and patterns between individuals. We aimed to investigate the association …

Why is iron deficiency/anemia linked to Alzheimer's disease and its comorbidities, and how is it prevented?

K Fehsel - Biomedicines, 2023 - mdpi.com
Impaired iron metabolism has been increasingly observed in many diseases, but a deeper,
mechanistic understanding of the cellular impact of altered iron metabolism is still lacking. In …

Differential expression of nuclear-encoded mitochondrial protein genes of ATP synthase across different tissues of female buffalo

EM Sadeesh, MS Lahamge, A Malik… - Molecular Biotechnology, 2025 - Springer
The physiological well-being of buffaloes, encompassing phenotypic traits, reproductive
health, and productivity, depends on their energy status. Mitochondria, the architects of …

[HTML][HTML] Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

J Raffin, Y Rolland, A Genoux, G Combes… - Journal of Sport and …, 2024 - Elsevier
Background Adenosine triphosphatase inhibitory factor 1 (IF1) is a key protein involved in
energy metabolism. IF1 has been linked to various age-related diseases, although its …

New Player in an Old Field? Ecto-F1-ATPase in Antidiabetic Actions of HDL in Pancreatic β-Cells

C Mineo, PW Shaul - Arteriosclerosis, thrombosis, and vascular …, 2024 - Am Heart Assoc
Prospective, observational studies have consistently demonstrated that low levels of
circulating HDL (high-density lipoprotein) are a hallmark of the metabolic syndrome and a …

Lp (a) concentration and polymorphic size are not associated with new onset diabetes in individuals with prediabetes

M Carpentier, M Wargny, M Croyal, C Le May… - Diabetes & …, 2025 - Elsevier
Aim Observational studies in the general population suggest that low concentrations of
lipoprotein (a)[Lp (a)] are associated with an increased risk of type 2 diabetes. Here, we aim …

The characteristic activity of regulatory B cells during the occurrence and development of insulin resistance

L Wei, L Zhang, D Zhao, Y Ma, L Yang - Endocrine, 2024 - Springer
Purpose To investigate the aberrant distribution and clinical relevance of regulatory B cells
(Bregs) subsets in the peripheral blood of individuals with different levels of insulin …