TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Background Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …

Workers in the mining and construction industries are at increased risk of respiratory and
other diseases as a result of being exposed to harmful levels of airborne particulate matter …

The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

Pulmonary fibrosis is characterised by excessive scarring in the lung which leads to
compromised lung function, serious breathing problems and in some diseases, death. It …

Alterations in the composition of the extracellular matrix (ECM) critically regulate the cellular
responses in tissue repair, remodeling, and fibrosis. After injury, proteolytic degradation of …

The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …