Cellular senescence is a state comprising an essentially irreversible proliferative arrest
combined with phenotypic changes and pronounced secretory activity. Although …

Nerve dependence has long been described in animal regeneration, where the outgrowth of
axons is necessary to the reconstitution of lost body parts and tissue remodeling in various …

Salamanders are tetrapod models to study brain organization and regeneration; however,
the identity and evolutionary conservation of brain cell types are largely unknown. We …

INTRODUCTION Axolotls (Ambystoma mexicanum) and other salamanders are the only
tetrapods that can regenerate whole limbs. During this complex process, changes in gene …

Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated
effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …

Abstract Model organisms are widely used in research as accessible and convenient
systems to study a particular area or question in biology. Traditionally only a handful of …

Limb regeneration, while observed lifelong in salamanders, is restricted in post-
metamorphic Xenopus laevis frogs. Whether this loss is due to systemic factors or an …

Salamanders regenerate appendages via a progenitor pool called the blastema. The
cellular mechanisms underlying regeneration of muscle have been much debated but have …

Recent advances in limb regeneration are revealing the molecular events that integrate
growth control, cell fate programming, and positional information to yield the exquisite …