Defects in cellular functions related to altered protein homeostasis and associated
progressive accumulation of pathological intracellular material is a critical process involved …

Remodeling of cytoskeleton structures, such as microtubule assembly, is believed to be
crucial for growth cone initiation and regrowth of injured axons. Autophagy plays important …

Chondroitin sulfate (CS) and heparan sulfate (HS) are glycosaminoglycans that both bind
the receptor-type protein tyrosine phosphatase PTPRσ, affecting axonal regeneration. CS …

Accidents are the cause of some 50 deaths per 100,000 population each year; some 3% of
these are from traumatic spinal cord injury (SCI), a damage that causes temporary or …

The objective of this study was to explore the neuroprotective molecular mechanisms of
erythropoietin (EPO) in rats following spinal cord injury (SCI). First, a standard SCI model …

It is well established that CNS axons fail to regenerate, undergo retrograde dieback, and
form dystrophic growth cones due to both intrinsic and extrinsic factors. We sought to …

Previous studies have indicated that spinal cord injury can induce autophagy. To a certain
extent, increased autophagy has a protective effect on neurons. Early hormone therapy is …

Traumatic spinal cord injuries result in impairment or even complete loss of motor, sensory
and autonomic functions. Recovery after complete spinal cord injury is very limited even in …

Background: Axonal degeneration is a key and early pathological feature in
neurodegenerative and traumatic disorders of the central nervous system. A focal lesion to …

The failure of axonal regeneration is due to myriad reasons both cell intrinsic and extrinsic.
In this thesis, I sought to investigate an intrinsic reason for regeneration failure in the CNS …