Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

Nucleic acids drugs have been proven in the clinic as a powerful modality to treat inherited
and acquired diseases. However, key challenges including drug stability, renal clearance …

Long noncoding RNAs (lncRNAs) have emerged as an important class of molecules that
regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels …

DNAzymes, generated through in vitro selection processes, are single-stranded DNA
catalysts that can catalyze a wide variety of reactions, such as RNA or DNA cleavage and …

In 1868, Friedrich Miescher completed his medical training and joined the physiological
chemistry laboratory of Felix Hoppe-Seyler to study the chemical composition of biological …

One of the most outstanding observations from next‐generation sequencing approaches
was that only 1.5% of our genes code for proteins. The biggest part is transcribed but give …

Introduction: Long non-coding RNAs (lncRNAs) are a recently discovered class of non-
coding functional RNA which has attracted immense research interest. The growing corpus …

Abstract microRNAs (miRNA) are small non-coding RNAs (sRNA) that post-transcriptionally
regulate gene (mRNA) expression and are implicated in many biological processes and …

DNAzymes exhibit high potential as gene silencing agents for therapeutic applications. Such
purposes, however, are significantly challenged by the targeted and successful delivery of …

The zebrafish (Danio rerio) is a versatile model organism that has been used in biomedical
research for several decades to study a wide range of biological phenomena. There are …