Deuterium‐and tritium‐labelled compounds: applications in the life sciences

J Atzrodt, V Derdau, WJ Kerr… - Angewandte chemie …, 2018 - Wiley Online Library
Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

Current status of animal models of posttraumatic stress disorder: behavioral and biological phenotypes, and future challenges in improving translation

J Deslauriers, M Toth, A Der-Avakian, VB Risbrough - Biological psychiatry, 2018 - Elsevier
Increasing predictability of animal models of posttraumatic stress disorder (PTSD) has
required active collaboration between clinical and preclinical scientists. Modeling PTSD is …

Deuterium-Depleted Water Influence on the Isotope 2H/1H Regulation in Body and Individual Adaptation

A Basov, L Fedulova, M Baryshev, S Dzhimak - Nutrients, 2019 - mdpi.com
This review article presents data about the influence of deuterium-depleted water (DDW) on
biological systems. It is known that the isotope abundances of natural and bottled waters are …

Reduction of deuterium level supports resistance of neurons to glucose deprivation and hypoxia: Study in cultures of neurons and on animals

A Kravtsov, S Kozin, A Basov, E Butina, M Baryshev… - Molecules, 2021 - mdpi.com
The effect of a reduced deuterium (D) content in the incubation medium on the survival of
cultured neurons in vitro and under glucose deprivation was studied. In addition, we studied …

Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes

A Basov, L Fedulova, E Vasilevskaya, S Dzhimak - Molecules, 2019 - mdpi.com
This article presents the original descriptions of some recent physics mechanisms (based on
the thermodynamic, kinetic, and quantum tunnel effects) providing stable 2H/1H isotope …

Deuterium‐und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften

J Atzrodt, V Derdau, WJ Kerr, M Reid - Angewandte Chemie, 2018 - Wiley Online Library
Wasserstoffisotope sind einzigartige Werkzeuge zur Identifizierung und Erforschung
biologischer oder chemischer Vorgänge. Wasserstoffisotopenmarkierungen erlauben den …

Effects of chronic unpredictable mild stress on ovarian reserve in female rats: Feasibility analysis of a rat model of premature ovarian failure

XY Fu, HH Chen, N Zhang… - Molecular …, 2018 - spandidos-publications.com
Premature ovarian failure (POF) results from a number of disorders. The POF model is
primarily based on chemotherapeutic injury, and hence is not suitable for assessing the …

Targeted neurotransmitters profiling identifies metabolic signatures in rat brain by LC-MS/MS: application in insomnia, depression and Alzheimer's disease

H Xu, Z Wang, L Zhu, Z Sui, W Bi, R Liu, K Bi, Q Li - Molecules, 2018 - mdpi.com
Epidemiological, cross-sectional, and prospective studies have suggested that insomnia,
Alzheimer's disease (AD) and depression are mutually interacting conditions and frequently …

Hippocampal over-expression of cyclooxygenase-2 (COX-2) is associated with susceptibility to stress-induced anhedonia in mice

T Strekalova, D Pavlov, A Trofimov… - International journal of …, 2022 - mdpi.com
The phenomenon of individual variability in susceptibility/resilience to stress and
depression, in which the hippocampus plays a pivotal role, is attracting increasing attention …

Increased oxidative stress in the prefrontal cortex as a shared feature of depressive-and PTSD-like syndromes: Effects of a standardized herbal antioxidant

J De Munter, D Pavlov, A Gorlova, M Sicker… - Frontiers in …, 2021 - frontiersin.org
Major depression (MD) and posttraumatic stress disorder (PTSD) share common brain
mechanisms and treatment strategies. Nowadays, the dramatically developing COVID-19 …