[HTML][HTML] MiR-223-3p in cancer development and cancer drug resistance: same coin, different faces
MicroRNAs (miRNAs) are mighty post-transcriptional regulators in cell physiology and
pathophysiology. In this review, we focus on the role of miR-223-3p (henceforth miR-223) in …
pathophysiology. In this review, we focus on the role of miR-223-3p (henceforth miR-223) in …
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
Identification of dietary bioflavonoids as potential inhibitors against KRAS G12D mutant—novel insights from computer-aided drug discovery
PS Ramalingam, P Balakrishnan, S Rajendran… - Current Issues in …, 2023 - mdpi.com
The KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and
lung, and has remained undruggable for the past three decades, due to its smooth surface …
lung, and has remained undruggable for the past three decades, due to its smooth surface …
Synthesis, in vitro and structural aspects of cap substituted Suberoylanilide hydroxamic acid analogs as potential inducers of apoptosis in Glioblastoma cancer cells …
JR Mekala, PS Ramalingam, S Mathavan… - Chemico-biological …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is a heterogeneous, aggressive brain cancer characterized
by chemo-resistance and cancer stemness. Histone deacetylases (HDACs) are a group of …
by chemo-resistance and cancer stemness. Histone deacetylases (HDACs) are a group of …
Purification, characterization, and biological activities of melanin pigment isolated from Indian squid Uroteuthis duvaucelii
S Elangovan, S Arumugam - Aquaculture International, 2023 - Springer
Melanin is a natural pigment present in plants, animals, humans, and pigment-producing
bacteria. Due to their biocompatibility and versatile biological activities, it was heavily used …
bacteria. Due to their biocompatibility and versatile biological activities, it was heavily used …
A green one-pot synthetic protocol of hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one derivatives: molecular docking, ADMET, anticancer and antimicrobial studies
Abstract Ten hexahydropyrimido [4, 5-d] pyrimidine derivatives have been synthesized by
using a green and time-efficient microwave method. The synthesized motifs were evaluated …
using a green and time-efficient microwave method. The synthesized motifs were evaluated …
Computational identification and experimental validation of potential inhibitors of JAK1 kinase from natural source for the effective treatment of colorectal …
Colorectal cancer (CRC) has become a global threat worldwide with constantly increasing
incidence and mortality rates every year, especially in the US and China. Janus kinase …
incidence and mortality rates every year, especially in the US and China. Janus kinase …
Synthesis of 8-methyl-2-phenylquinazolin-4 (3H)-ones derived Schiff's bases: Spectroscopic properties, SAR, docking approaches and their anticancer and …
A series of new compounds based on 8-methyl-2-phenyl quinazolinone Schiff's base were
synthesized from 3-amino quinazolinone intermediates. These compounds were evaluated …
synthesized from 3-amino quinazolinone intermediates. These compounds were evaluated …
[HTML][HTML] Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico …
Ten new non-nucleophilic base (DBU) catalyzed oxazolone-bearing pyrazole derivatives
were created to treat infectious diseases caused by bacterial, mycobacterial strains, and …
were created to treat infectious diseases caused by bacterial, mycobacterial strains, and …
Copper modulates mitochondrial oxidative phosphorylation to enhance dermal papilla cells proliferation in rex rabbits
F Li, H Liu, X Wu, M Liu, Z Yue, L Liu, F Li - International Journal of …, 2022 - mdpi.com
Copper (Cu) is an important coenzyme factor in cell signaling, such as cytochrome c oxidase
(Complex IV). Metabolism plays an important role in regulating the fate of mammalian cells …
(Complex IV). Metabolism plays an important role in regulating the fate of mammalian cells …