The structural factor of hypertension: large and small artery alterations

S Laurent, P Boutouyrie - Circulation research, 2015 - Am Heart Assoc
Pathophysiological studies have extensively investigated the structural factor in
hypertension, including large and small artery remodeling and functional changes. Here, we …

Age-related vascular stiffening: causes and consequences

JC Kohn, MC Lampi, CA Reinhart-King - Frontiers in genetics, 2015 - frontiersin.org
Arterial stiffening occurs with age and is closely associated with the progression of
cardiovascular disease. Stiffening is most often studied at the level of the whole vessel …

Spontaneous coronary artery dissection: clinical outcomes and risk of recurrence

J Saw, K Humphries, E Aymong, T Sedlak… - Journal of the American …, 2017 - jacc.org
Background: Spontaneous coronary artery dissection (SCAD) is underdiagnosed and an
important cause of myocardial infarction (MI), especially in young women. Long-term …

Mechanisms, pathophysiology, and therapy of arterial stiffness

SJ Zieman, V Melenovsky, DA Kass - … , thrombosis, and vascular …, 2005 - Am Heart Assoc
Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular
events, dementia, and death. Decreased compliance of the central vasculature alters arterial …

Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study

GF Mitchell, H Parise, EJ Benjamin, MG Larson… - …, 2004 - Am Heart Assoc
With advancing age, arterial stiffness and wave reflections increase and elevate systolic and
pulse pressures. An elevated central pulse pressure is generally ascribed to increased wave …

Twisted blood vessels: symptoms, etiology and biomechanical mechanisms

HC Han - Journal of vascular research, 2012 - karger.com
Tortuous arteries and veins are commonly observed in humans and animals. While mild
tortuosity is asymptomatic, severe tortuosity can lead to ischemic attack in distal organs …

Cardiovascular effects of exercise training: molecular mechanisms

S Gielen, G Schuler, V Adams - Circulation, 2010 - Am Heart Assoc
In the natural habitat of our ancestors, physical activity was not a preventive intervention but
a matter of survival. In this hostile environment with scarce food and ubiquitous dangers …

Noninvasive assessment of arterial stiffness and risk of atherosclerotic events

JJ Oliver, DJ Webb - Arteriosclerosis, thrombosis, and vascular …, 2003 - Am Heart Assoc
Investigation of arterial stiffness, especially of the large arteries, has gathered pace in recent
years with the development of readily available noninvasive assessment techniques. These …

Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review

A Tsamis, JT Krawiec, DA Vorp - Journal of the royal …, 2013 - royalsocietypublishing.org
Aortic disease is a significant cause of death in developed countries. The most common
forms of aortic disease are aneurysm, dissection, atherosclerotic occlusion and ageing …

Pulse pressure—a review of mechanisms and clinical relevance

AM Dart, BA Kingwell - Journal of the American College of Cardiology, 2001 - jacc.org
The goal of this study was to review the origin, clinical relevance and treatment of pulse
pressure (PP). Elevated PP is increasingly being recognized as a risk factor for …