A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization
O Ebenezer, M Shapi, JA Tuszynski - International Journal of Molecular …, 2022 - mdpi.com
Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …
Antioxidants in Oak (Quercus sp.): Potential Application to Reduce Oxidative Rancidity in Foods
ED Othón-Díaz, JO Fimbres-García, M Flores-Sauceda… - Antioxidants, 2023 - mdpi.com
This review explores the antioxidant properties of oak (Quercus sp.) extracts and their
potential application in preventing oxidative rancidity in food products. Oxidative rancidity …
potential application in preventing oxidative rancidity in food products. Oxidative rancidity …
Anti‐inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate …
G Sudhakaran, P Prathap, A Guru… - Cell Biology …, 2022 - Wiley Online Library
Human health may benefit from the study of natural compounds and phytoconstituents that
can protect from inflammation. We investigated Nimbin (N1), a member of the ring C Seco …
can protect from inflammation. We investigated Nimbin (N1), a member of the ring C Seco …
Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway …
Polycystic ovarian syndrome (PCOS) is a hormonal disorder that causes enlargement of
ovaries and follicular maturation arrest, which lacks efficient treatment. N2, a semi‐natural …
ovaries and follicular maturation arrest, which lacks efficient treatment. N2, a semi‐natural …
Protective effect of morin by targeting mitochondrial reactive oxygen species induced by hydrogen peroxide demonstrated at a molecular level in MDCK epithelial cells
Background The development of diabetic nephropathy is aided by the presence of oxidative
stress. Morin, a natural flavonoid molecule, has been shown to have antioxidant and anti …
stress. Morin, a natural flavonoid molecule, has been shown to have antioxidant and anti …
[HTML][HTML] Metabolic diversity, biosynthetic pathways, and metabolite biomarkers analysed via untargeted metabolomics and the antioxidant potential reveal for high …
High-temperature tolerant varieties/hybrids of tomato overcome stress-related changes due
to their intrinsic cellular metabolic capabilities. We have used untargeted metabolite profiling …
to their intrinsic cellular metabolic capabilities. We have used untargeted metabolite profiling …
Synthesis, bioactivity, pharmacokinetic and biomimetic properties of multi-substituted coumarin derivatives
A Katopodi, E Tsotsou, T Iliou, GE Deligiannidou… - Molecules, 2021 - mdpi.com
A series of novel multi-substituted coumarin derivatives were synthesized, spectroscopically
characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) …
characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) …
Synthesis of tetracyclic spirooxindolepyrrolidine-engrafted hydantoin scaffolds: crystallographic analysis, molecular docking studies and evaluation of their …
A Toumi, FIA Abdella, S Boudriga, TYA Alanazi… - Molecules, 2023 - mdpi.com
In a sustained search for novel potential drug candidates with multispectrum therapeutic
application, a series of novel spirooxindoles was designed and synthesized via …
application, a series of novel spirooxindoles was designed and synthesized via …
Antifungal activities of fluorinated pyrazole aldehydes on phytopathogenic fungi, and their effect on entomopathogenic nematodes, and soil-beneficial bacteria
V Rastija, K Vrandečić, J Ćosić, G Kanižai Šarić… - International journal of …, 2023 - mdpi.com
Fluoro-substituted pyrazoles have a wide range of biological activities, such as antibacterial,
antiviral, and antifungal activities. The aim of this study was to evaluate the antifungal …
antiviral, and antifungal activities. The aim of this study was to evaluate the antifungal …
Green synthesis of thiazolidine-2, 4-dione derivatives and their lipoxygenase inhibition activity with QSAR and molecular docking studies
Thiazolidinediones are five-membered, heterocyclic compounds that possess a number of
pharmacological activities such as antihyperglycemic, antitumor, antiarthritic, anti …
pharmacological activities such as antihyperglycemic, antitumor, antiarthritic, anti …